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| Lopes,Clarissa Elize; Langoski,Gisele; Klein,Traudi; Ferrari,Priscileila Colerato; Farago,Paulo Vitor. |
| ABSTRACT Halcinonide is a high-potency topical glucocorticoid used for skin inflammation treatments that presents toxic systemic effects. A simple and quick analytical method to quantify the amount of halcinonide encapsulated into lipid nanoparticles, such as polymeric lipid-core nanoparticles and solid lipid nanoparticles, was developed and validated regarding the drug's encapsulation efficiency and in vitro permeation. The development and validation of the analytical method were carried out using the high performance liquid chromatography with the UV detection at 239 nm. The validation parameters were specificity, linearity, precision and accuracy, limits of detection and quantitation, and robustness. The method presented an isocratic flow rate of 1.0... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Halcinonide/encapsulation efficiency; Halcinonide/quantification; Polymeric lipid-core nanoparticles; Solid lipid nanoparticles; Topical administration; Toxicity; High performance liquid chromatography/method validation. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200604 |
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