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	Provedor de dados BJMBR (2) Autor Carrithers,S.L. (1) Fonteles,M.C. (1) Forte,L.R. (1) Giannella,R.A. (1) Greenberg,R.N. (1) Hill,M.J. (1) Jackson,B.A. (1) Johnson,B.R. (1) Lima,A.A.M. (1) Lorenz,J. (1) Mann,E.A. (1) O'Hara,S.M. (1) Ott,C.E. (1) Mais... Palavra-chave Heat-stable enterotoxin (2) Differential display PCR (1) Electrolyte and water balance (1) Guanylin (1) Guanylyl cyclase (1) Guanylyl cyclase C (1) Kidney (1) Kidney function (1) Natriuresis (1) Secretory diarrhea (1) Sodium-potassium ATPase (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2014 (1) 1999 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última From Escherichia coli heat-stable enterotoxin to mammalian endogenous guanylin hormones BJMBR Lima,A.A.M.; Fonteles,M.C.. The isolation of heat-stable enterotoxin (STa) from Escherichia coli and cholera toxin from Vibrio cholerae has increased our knowledge of specific mechanisms of action that could be used as pharmacological tools to understand the guanylyl cyclase-C and the adenylyl cyclase enzymatic systems. These discoveries have also been instrumental in increasing our understanding of the basic mechanisms that control the electrolyte and water balance in the gut, kidney, and urinary tracts under normal conditions and in disease. Herein, we review the evolution of genes of the guanylin family and STa genes from bacteria to fish and mammals. We also describe new developments and perspectives regarding these novel bacterial compounds and peptide hormones that act in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Heat-stable enterotoxin; Guanylin; Guanylyl cyclase; Secretory diarrhea; Kidney function; Electrolyte and water balance. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000300179 Renal effects of uroguanylin and guanylin in vivo BJMBR Carrithers,S.L.; Hill,M.J.; Johnson,B.R.; O'Hara,S.M.; Jackson,B.A.; Ott,C.E.; Lorenz,J.; Mann,E.A.; Giannella,R.A.; Forte,L.R.; Greenberg,R.N.. Uroguanylin and guanylin are newly discovered endogenous heat-stable peptides that bind to and activate a membrane bound guanylyl cyclase signaling receptor (termed guanylyl cyclase C; GC-C). These peptides are not only found in blood but are secreted into the lumen of the intestine and effect a net secretion of electrolytes (Na+, K+, Cl-, HCO3-) and fluid into the intestine via a cyclic guanosine-3',5'-monophosphate (cGMP) mechanism. GC-C is also the receptor for Escherichia coli heat-stable enterotoxin (STa) and activation by STa results in a diarrheal illness. Employing mouse renal in vivo models, we have demonstrated that uroguanylin, guanylin, and STa elicit natriuretic, kaliuretic, and diuretic effects. These biological responses are time- and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Guanylyl cyclase C; Heat-stable enterotoxin; Kidney; Natriuresis; Sodium-potassium ATPase; Differential display PCR. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100003 Registros recuperados: 2 Primeira ... 1 ... Última

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