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	Provedor de dados BJMBR (2) Autor Pereira,F.A. (2) Defino,H.L.A. (1) Facincani,I. (1) Fernandes,M.I.M. (1) Jorgetti,V. (1) Mattar,R. (1) Nogueira-Barbosa,M.H. (1) Paula,F.J.A. (1) Paula,F.J.A. de (1) Ramalho,L.N.Z. (1) Sawamura,R. (1) Taveira,A.T.A. (1) Volpon,J.B. (1) Mais... Palavra-chave Hepatic osteodystrophy (2) Animal models (1) Biomechanics (1) Bone mineral density (1) Bone remodeling (1) Growth factors (1) Insulin-like growth factor-I (1) Osteoporosis (1) Osteoporosis pathogenesis (1) Pamidronate (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2012 (1) 2010 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Pamidronate for the treatment of osteoporosis secondary to chronic cholestatic liver disease in Wistar rats BJMBR Pereira,F.A.; Mattar,R.; Facincani,I.; Defino,H.L.A.; Ramalho,L.N.Z.; Jorgetti,V.; Volpon,J.B.; Paula,F.J.A. de. Osteoporosis is a major complication of chronic cholestatic liver disease (CCLD). We evaluated the efficacy of using disodium pamidronate (1.0 mg/kg body weight) for the prevention (Pr) or treatment (Tr) of cholestasis-induced osteoporosis in male Wistar rats: sham-operated (Sham = 12); bile duct-ligated (Bi = 15); bile duct-ligated animals previously treated with pamidronate before and 1 month after surgery (Pr = 9); bile duct-ligated animals treated with pamidronate 1 month after surgery (Tr = 9). Rats were sacrificed 8 weeks after surgery. Immunohistochemical expression of IGF-I and GH receptor was determined in the proximal growth plate cartilage of the left tibia. Histomorphometric analysis was performed in the right tibia and the right femur was used... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatic osteodystrophy; Osteoporosis pathogenesis; Growth factors; Biomechanics; Animal models; Pamidronate. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200021 Longitudinal evaluation of hepatic osteodystrophy in children and adolescents with chronic cholestatic liver disease BJMBR Taveira,A.T.A.; Pereira,F.A.; Fernandes,M.I.M.; Sawamura,R.; Nogueira-Barbosa,M.H.; Paula,F.J.A.. Bone mass loss is a major complication of chronic cholestatic liver disease (CCD). However, the long-term impact of CCD on bone mass acquisition is unknown. We longitudinally assessed bone mineral density (BMD) and factors involved in bone remodeling in 9 children and adolescents with CCD Child-Pugh A (5 boys/4 girls) and in 13 controls (6 boys/7 girls). The groups were evaluated twice, at baseline (T0) and after 3 years (T1), when osteocalcin, deoxypyridinoline, 25-hydroxyvitamin-D, parathyroid hormone, insulin-like growth factor-I (IGF-I), and BMD (L1-L4, proximal femur and total body) were determined. Serum levels of receptor activator for nuclear factor kB ligand (RANKL) and osteoprotegerin were measured only at T1. Lumbar spine BMD was reanalyzed... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatic osteodystrophy; Insulin-like growth factor-I; Osteoporosis; Bone mineral density; Bone remodeling. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100017 Registros recuperados: 2 Primeira ... 1 ... Última

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