SABIIA - Sistema Aberto e Integrado de Informação em Agricultura (Sabiia)

Costa,Luciano Bello; Ferraz,Maria Lucia Gomes; Perez,Renata M.; Ferreira,Adalgisa S.; Matos,Carla Adriana L.; Lanzoni,Valéria P.; Silva,Antônio Eduardo.

There is increasing interest in the identification of factors associated with liver disease progression in patients infected with hepatitis C virus (HCV). We assessed host-related factors associated with a histologically advanced stage of this disease and determined the rate of liver fibrosis progression in HCV-infected patients. We included patients submitted to liver biopsy, who were anti-HCV and HCV RNA positive, who showed a parenteral risk factor (blood transfusion or intravenous drug use), and who gave information about alcohol consumption.Patients were divided into two groups for analysis: group 1 - grades 0 to 2; group 2 - grades 3 to 4. The groups were compared in terms of sex, age at the time of infection, estimated duration of infection and...

Hepatitis C prevalence among men who have sex with men in Central Brazil

Palavras-chave: Hepatitis C virus; Liver fibrosis; Patients.

Ano: 2002

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500002

Andrade,Andreia Alves de; Silva,Ágabo Macêdo da Costa e; Carneiro,Megmar Aparecida dos Santos; Teles,Sheila Araújo; Martins,Regina Maria Bringel.

Abstract To assess the prevalence of hepatitis C virus infection among men who have sex with men (MSM) in Central Brazil, a cross-sectional study was conducted in the City of Goiânia, Central Brazil, using Respondent-Driven Sampling (RDS). All serum samples were tested for anti-HCV and also for alanine aminotransferase (ALT). Anti-HCV positive samples and/or those with elevated ALT were tested for HCV RNA and genotyped. Of the 522 participants, four were found to be anti-HCV positive, and one was also HCV RNA positive (active HCV infection). Elevated ALT was found in 14 individuals. Of these, one showed evidence of acute HCV infection (HCV RNA positive and anti-HCV negative). Therefore, five MSM were positive for either anti-HCV and/or HCV RNA, giving a...

CD81 binding regions of hepatitis C virus remain conserved after liver transplantation

Palavras-chave: Hepatitis C virus; Men who have sex with men; Prevalence; Brazil.

Ano: 2019

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400271

Lyra,Andre C.; Fan,Xiaofeng; Di Bisceglie,Adrian M..

CD81 is a surface-associated protein expressed in the membranes of mammalian cells. It has been suggested that CD81 interacts with hepatitis C virus E2 protein, and thus might facilitate the entry of HCV into hepatocytes. The envelope-binding site appears to involve amino acids (aa) 480-493 and 544-551 within the E2 glycoprotein. Little is known about the quasispecies genetic diversity of these two regions. We studied four patients who underwent transplantation for HCV-related cirrhosis and who developed recurrent hepatitis C. We evaluated HCV quasispecies diversity in serum samples obtained at the time of transplantation and at several time points thereafter. Quasispecies diversity was assessed by cloning and sequencing of viral isolates, with computer...

Chronic hepatitis C virus in the state of Piauí, northeastern Brazil

Palavras-chave: Hepatitis C virus; CD81; Diversity.

Ano: 2004

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200002

Veras,Kelson Nobre; Jacobina,Kelson Sousa; Soares,Vítor Y. Rocha; Avelino,Marcela Amaral; Vasconcelos,Conceição de Maria S.R.; Parente,José Miguel L..

Knowledge of genotype distribution of hepatitis C virus (HCV) has clinical importance due to genotype 1 lower response to treatment compared with genotypes 2 and 3. The goal of this survey was to describe clinical and laboratorial profiles of patients with chronic hepatitis C (CHC) in the State of Piauí, as well as to expand the overall awareness of the distribution of HCV genotyping in Northeast of Brazil. A retrospective cross-sectional study was carried out between April 1999 and August 2005. A total of 153 patients were included, 119 (77.8%) males and 34 (22.2%) females; mean age = 48.01 ± 9.11 years. We observed a homogeneous distribution between genotypes 1 (50.0%) and 3 (49.0%), while the most frequent subtype noticed was 3a (49.0%). The mean viral...

Extended treatment with interferon and ribavirin in a hemodialysis patient with chronic hepatitis C

Palavras-chave: Epidemiology; Hepatitis C virus; Genotype distribution; Chronic hepatitis C.

Ano: 2009

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200011

Vigani,Aline Gonzalez; Pavan,Maria HP; Tozzo,Raquel; Gonçales,Eduardo SL; Lazarini,Maria SK; Oliveira,Alexandre Macedo de; Gonçales Jr,Fernando L.

Hemodialysis patient with chronic HCV infection,who was started on monotherapy with interferon.Qualitative HCV RNA remained positive at 12 weeks of treatment; ribavirin was associated. HCV RNA was negative at week 24 and treatment was extended to 72 weeks. HCV RNA negative six months after treatment.

Tipo: Info:eu-repo/semantics/report

Palavras-chave: Hepatitis C virus; Hemodialysis; Treatment; Interferon; Ribavirin.

Ano: 2010

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200016

Viral hepatitis in patients infected with human immunodeficiency virus

Pavan,Maria Helena P.; Aoki,Francisco Hideo; Monteiro,Dinaida Teresa; Gonçales,Neiva Sellan L.; Escanhoela,Cecília Amélia F.; Gonçales Júnior,Fernando L..

From 1992 to 1995 we studied 232 (69% male, 87% Caucasian) anti-human immunodeficiency virus (anti-HIV) positive Brazilian patients, through a questionnaire; HIV had been acquired sexually by 50%, from blood by 32%, sexually and/or from blood by 16.4% and by an unknown route by 1.7%. Intravenous drug use was reported by 29%; it was the most important risk factor for HIV transmission. The alanine aminotransferase quotient (qALT) was >1 for 40% of the patients, 93.6% had anti-hepatitis A virus antibody, 5.3% presented hepatitis B surface antigen, 44% were anti-hepatitis B core antigen positive and 53.8% were anti-hepatitis C virus (anti-HCV) positive. The anti-HCV test showed a significant association with qALT>1. Patients for whom the probable HIV...

Previous hepatitis E virus infection, cirrhosis and insulin resistance in patients with chronic hepatitis C

Palavras-chave: Hepatitis C virus; Human immunodeficiency virus; Alanine aminotransferase quotient; Anti-hepatitis A antibody; Hepatitis B surface antigen; Anti-hepatitis B core antigen (anti-HBc).

Ano: 2003

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400005

Bricks,Guilherme; Senise,Jorge Figueiredo; Pott-Jr,Henrique; Grandi,Giuliano; Carnaúba-Jr,Dimas; Moraes,Hamilton Antonio Bonilha de; Granato,Celso Franscisco Hernandes; Castelo,Adauto.

ABSTRACT Background: Hepatitis E virus (HEV) infection in patients with pre-existing liver disease has shown high morbidity and lethality. The consequences of HEV superinfection in patients with chronic hepatitis C virus (HCV) infection are not fully understood. This study aimed to evaluate the association between the presence of anti-HEV antibodies, liver cirrhosis, and insulin resistance. Methods: A total of 618 patients chronically infected with HCV were included from three reference centers for viral hepatitis in São Paulo, Brazil. Presence of anti-HEV IgG was assessed by enzyme-linked immunosorbent assay (WANTAI HEV-IgG ELISA). Results: The seroprevalence of anti-HEV in patients with cirrhosis was significantly higher than in patients without...

Splenectomy prior to antiviral therapy in patients with hepatitis C virus related decompensated cirrhosis

Palavras-chave: Hepatitis E virus; Hepatitis C virus; Liver cirrhosis; Insulin resistance.

Ano: 2019

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100045

Fanpu,Ji; Zhang,Shu; Huang,Na; Deng,Hong; Li,Zongfang.

Patients with hepatitis C virus-related decompensated cirrhosis can benefit frominterferonbased antiviral therapy, but the common complication of cytopenia is a contraindication for this treatment. Splenectomy prior to interferon therapy may alleviate this problem. To investigate whether splenectomy improves the efficacy of antiviral therapy, 13 interferonnaïve hepatitis C virus decompensated cirrhotic patients underwent splenectomy between January 2008 and January 2011, followed 1-3 months later by an interferon-based therapeutic regimen (pegylated/standard interferon-α combined with ribavirin for 48 weeks). Ten (76.9%) of the patients developed postoperative complications, which included minor portal vein thrombosis (2/13, 15.4%) and transient ascites...

Induction with ribavirin in a relapsing patient with chronic HCV hepatitis

Palavras-chave: Hepatitis C virus; Thrombocytopenia; Splenectomy; Antiviral therapy.

Ano: 2013

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500014

Seroprevalence of hepatitis E virus in chronic hepatitis C in Brazil

Ucciferri,Claudio; Mancino,Paola; Vignale,Francesca; Vecchiet,Jacopo; Falasca,Katia.

In this case, a new possible strategy for treatment of hepatitis C virus (HCV) relapsing patients is described. The target of anti-HCV therapy is sustained viral response, but strategies for improving sustained viral response in relapsing patients would be useful, and ribavirin is crucial for obtaining viral response. Six weeks of induction therapy with ribavirin were used to improve efficacy of standard combined antiviral therapy in a patient relapsing to standard therapy. In the present case, the patient had undergone a retreatment with the same regimen with the exception of the six-week induction period with ribavirin. Use of induction therapy with ribavirin in this case has allowed for a sustained viral response without prolonging the interferon...

Tipo: Info:eu-repo/semantics/report

Palavras-chave: Induction; Re-treatment; Sustained viral response; Hepatitis C virus.

Ano: 2012

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300015

Bricks,Guilherme; Senise,Jorge Figueiredo; Pott Junior,Henrique; Grandi,Giuliano; Passarini,Amanda; Caldeira,Débora Bellini; Carnaúba Junior,Dimas; Moraes,Hamilton Antonio Bonilha de; Granato,Celso Franscisco Hernandes; Castelo,Adauto.

ABSTRACT Background and aims: Hepatitis E virus infection in patients with underlying chronic liver disease is associated with liver decompensation and increased lethality. The seroprevalence of hepatitis E virus in patients with chronic hepatitis C in Brazil is unknown. This study aims to estimate the seroprevalence of hepatitis E virus in patients with chronic hepatitis C and to describe associated risk factors. Methods: A total of 618 patients chronically infected with hepatitis C virus from three reference centers of São Paulo, Brazil were included. Presence of anti-HEV IgG was assessed by enzyme-linked immunosorbent assay (WANTAI HEV-IgG ELISA). Results: Out of the 618 patients tested, 10.2% turned out positive for anti-HEV IgG (95% CI 8.0–12.8%)....

Hepatitis C in hemodialysis: the contribution of injection drug use

Palavras-chave: Hepatitis E virus; Hepatitis C virus; Brazil; Seroprevalence.

Ano: 2018

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200085

Galperim,Bruno; Mattos,Angelo A; Stein,Airton T; Schneider,Nuttiane C; Buriol,André; Fonseca,André; Lunge,Vagner; Ikuta,Nilo.

BACKGROUND: Hepatitis C virus (HCV) infection is the most common cause of acute or chronic hepatitis in patients on hemodialysis (HD). The purpose of this study was to describe the prevalence of positive HCV RNA and investigate injection drug use as an emerging risk factor in patients with chronic renal disease on HD. METHODS: This was a multicenter cross-sectional study with 325 patients with chronic renal disease on HD in the period between August 1, 2005 to August 30, 2006, receiving care at four institutions in the city of Porto Alegre, Southern Brazil. Epidemiological data were collected by means of a structured questionnaire. The following laboratory tests were performed: alanine aminotransferase (ALT), anti-hepatitis C virus antibodies (anti-HCV),...

Is hepatitis C virus a cause of idiopathic dilated cardiomyopathy? A systematic review of literature

Palavras-chave: Hepatitis C virus; Hemodialysis; Injection drug use; Risk factors.

Ano: 2010

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400020

Reis,Francisco José Farias Borges dos; Sousa,Tiago Almeida de; Oliveira,Manoela S.; Dantas,Ney; Silveira,Martha; Braghiroly,Maria Ignês Freitas Melro; Paraná,Raymundo.

Recent studies have suggested that some patients with idiopathic dilated cardiomyopathy (IDC) are also afflicted with insidious forms of viral myocarditis. Participation of hepatitis C virus (HCV) in this process has been postulated. The objective of this study was to evaluate a possible association between hepatitis C virus and idiopathic dilated cardiomyopathy. Systematic review of the literature using electronic databases (MEDLINE, EMBASES, LILACS and COCHRANE) for the period from 1995 to 2005, limited to papers published in English, Spanish and Portuguese. Sixty-two papers were found, of which six were in accordance with the proposed methodology. After selection, the articles were classified by quality of data and number of variables studied. Most of...

Quality of life, risk behaviors and depression among carriers of hepatitis C virus and human T-cell lymphotropic virus type 1: a comparative study

Palavras-chave: Idiopathic dilated cardiomyopathy; Hepatitis C virus; Systematic review.

Ano: 2006

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300009

Henrique-Araújo,Ricardo; Quarantini,Lucas C.; Caribé,André C.; Argolo,Felipe C.; Jesus-Nunes,Ana Paula; Morais-de-Jesus,Mychelle; Dantas-Duarte,Adriana; Moreira,Tayne Miranda; Oliveira,Irismar Reis de.

Abstract Human T-cell lymphotropic virus type 1 (HTLV-1) has low prevalence rates, but is endemic in some regions of the world. It is usually a chronic asymptomatic infection, but it can be associated with serious neurologic and urinary conditions. Hepatitis C virus (HCV) is broadly spread out worldwide. The majority of these infections have a chronic course that may progress to cirrhosis and hepatocellular carcinoma. Objectives: To compare sociodemographic and mental health (risk behaviors, depression, and suicide) aspects, and quality of life among patients with HCV or HTLV-1. Methods: Observational, comparative and cross-sectional study involving outpatients with HCV or HLTV-1 infection. Sociodemographic characteristics, risk behaviors and quality of...

Prevalence of hepatitis C and B virus infection in patients with idiopathic dilated cardiomyopathy in Brazil: a pilot study

Palavras-chave: Hepatitis C virus; Human T-cell lymphotropic virus type 1; Quality of life; Risk behaviors; Depression; Suicide.

Ano: 2019

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400224

Reis,Francisco J.F.B.; Viana,Mateus; Oliveira,Manoela; Sousa,Tiago A.; Paraná,Raimundo.

The idiopathic dilated cardiomyopathy (IDMC) is a disease of the cardiac muscle characterized by systolic dilation and/or dysfunction of one or both ventricles, symptoms of congestive heart failure and risk of early death. Several studies in animal models and in humans have supported the hypothesis of the viral infection as initial event in the immunopathogenesis of the ventricular dilation. The objective of this study was to correlate the presence of hepatitis C virus chronic infection and idiopathic dilated cardiomyopathy, comparing samples of cases with IDCM with paired controls with Chagas-type specific dilated cardiomyopathy and ischemic-type specific dilated cardiomyopathy. Only 2.9% (1/34) of IDCM patients were HCV carriers, which strongly argue...

Hepatitis C as a risk factor for diabetes type 2: lack of evidence in a hospital in central-west Brazil

Palavras-chave: Idiopathic dilated cardiomyopathy; Hepatitis C virus; Myocarditis; Heart failure.

Ano: 2007

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300004

Costa,Luce Marina Freires Corrêa da; Mussi,Aparecida Duarte Hg; Brianeze,Marylina Rodrigues; Souto,Francisco José Dutra.

In order to assess the importance of HCV infection as a possible risk factor for type 2 diabetes mellitus, a case-control study was conducted, comparing the prevalence of HCV infection among diabetic and non-diabetic patients. Diabetic outpatients attending to a University Hospital in Central-West Brazil were evaluated between April and October 2005. A control group composed by patients from the same institution was matched by gender and age. Candidates to control group were included only if fasting glucose measures were under 100 mg/dL. Diabetics and controls had blood samples taken in order to test for antibodies against HCV (anti-HCV) by enzyme-immunoassay. Polymerase chain reaction and immunoblot were performed to confirm the anti-HCV status. Each...

Cost-effective analysis of different algorithms for the diagnosis of hepatitis C virus infection

Palavras-chave: Type 2 diabetes mellitus; Case control study; Risk factors; Hepatitis C virus; Epidemiology.

Ano: 2008

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100007

Barreto,A.M.E.C.; Takei,K.; E.C.,Sabino; Bellesa,M.A.O.; Salles,N.A.; Barreto,C.C.; Nishiya,A.S.; Chamone,D.F..

We compared the cost-benefit of two algorithms, recently proposed by the Centers for Disease Control and Prevention, USA, with the conventional one, the most appropriate for the diagnosis of hepatitis C virus (HCV) infection in the Brazilian population. Serum samples were obtained from 517 ELISA-positive or -inconclusive blood donors who had returned to Fundação Pró-Sangue/Hemocentro de São Paulo to confirm previous results. Algorithm A was based on signal-to-cut-off (s/co) ratio of ELISA anti-HCV samples that show s/co ratio ³95% concordance with immunoblot (IB) positivity. For algorithm B, reflex nucleic acid amplification testing by PCR was required for ELISA-positive or -inconclusive samples and IB for PCR-negative samples. For algorithm C, all...

Antiphospholipid antibodies in Brazilian hepatitis C virus carriers

Palavras-chave: Hepatitis C virus; Immunoblot; ELISA; Polymerase chain reaction; Algorithm; Diagnosis.

Ano: 2008

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200009

Atta,A.M.; Estevam,P.; Paraná,R.; Pereira,C.M.; Leite,B.C.O.; Sousa-Atta,M.L.B..

Hepatitis C, a worldwide viral infection, is an important health problem in Brazil. The virus causes chronic infection, provoking B lymphocyte dysfunction, as represented by cryoglobulinemia, non-organ-specific autoantibody production, and non-Hodgkin's lymphoma. The aim of this research was to screen for the presence of antiphospholipid autoantibodies in 109 Brazilian hepatitis C virus carriers without clinical history of antiphospholipid syndrome. Forty healthy individuals were used as the control group. IgA, IgG, and IgM antibodies against cardiolipin and β2-glycoprotein I were measured with an enzyme-linked immunosorbent assay, using a cut-off point of either 20 UPL or 20 SBU. While 24 (22.0%) hepatitis C carriers had moderate titers of IgM...

Hepatitis C virus infection among Brazilian hemophiliacs: a virological, clinical and epidemiological study

Palavras-chave: Hepatitis C virus; Antiphospholipid antibody; Brazilian patients.

Ano: 2008

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600009

Carmo,R.A.; Oliveira,G.C.; Guimarães,M.D.C.; Oliveira,M.S.; Lima,A.A.; Buzek,S.C.; Corrêa-Oliveira,R.; Rocha,M.O.C..

We determined and analyzed risk factors of hepatitis C virus (HCV)-infected Brazilian hemophiliacs according to their virological, clinical and epidemiological characteristics. A cross-sectional and retrospective study of 469 hemophiliacs was carried out at a Brazilian blood center starting in October 1997. The prevalence of HCV infection, HCV genotypes and factors associated with HCV RNA detection was determined. The seroprevalence of anti-HCV antibodies (ELISA-3.0) was 44.6% (209/469). Virological, clinical and epidemiological assessments were completed for 162 positive patients. There were seven (4.3%) anti-HCV seroconversions between October 1992 and October 1997. During the same period, 40.8% of the positive anti-HCV hemophiliacs had abnormal alanine...

Genotyping hepatitis C virus from hemodialysis patients in Central Brazil by line probe assay and sequence analysis

Palavras-chave: Hepatitis C virus; HCV genotypes; Hemophilia; Chronic liver disease; Transfusion; Brazil.

Ano: 2002

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500012

Espírito-Santo,M.P.; Carneiro,M.A.S.; Reis,N.R.S.; Kozlowski,A.G.; Teles,S.A.; Lampe,E.; Yoshida,C.F.T.; Martins,R.M.B..

The present study examined the distribution of hepatitis C virus (HCV) genotypes and subtypes in a hemodialysis population in Goiás State, Central Brazil, and evaluated the efficiency of two genotyping methods: line probe assay (LiPA) based on the 5' noncoding region and nucleotide sequencing of the nonstructural 5B (NS5B) region of the genome. A total of 1095 sera were tested for HCV RNA by RT-nested PCR of the 5' noncoding region. The LiPA assay was able to genotype all 131 HCV RNA-positive samples. Genotypes 1 (92.4%) and 3 (7.6%) were found. Subtype 1a (65.7%) was the most prevalent, followed by subtypes 1b (26.7%) and 3a (7.6%). Direct nucleotide sequencing of 340 bp from the NS5B region was performed in 106 samples. The phylogenetic tree showed that...

Distribution of the human leukocyte antigen class II alleles in Brazilian patients with chronic hepatitis C virus infection

Palavras-chave: Hepatitis C; Hepatitis C virus; Genotypes; Hemodialysis.

Ano: 2007

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000400013

Corghi,D.B.; Gonçales,N.S.L.; Marques,S.B.D.; Gonçales Jr.,F.L..

Hepatitis C virus (HCV) infection is a global medical problem. The current standard of treatment consists of the combination of peginterferon plus ribavirin. This regimen eradicates HCV in 55% of cases. The immune response to HCV is an important determinant of disease evolution and can be influenced by various host factors. HLA class II may play an important role in immune response against HCV. The objective of the present study was to determine the distribution of HLA class II (DRB1 and DQB1) alleles, their association with chronic HCV infection and their response to interferon therapy. One hundred and two unrelated white Brazilian patients with chronic HCV infection, 52 responders (45 males and 7 females) and 50 non-responders (43 males and 7 females) to...