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| Registros recuperados: 29 | |
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| Pessoa,Luciana Santos; Vidal,Luãnna Liebscher; Costa,Emmerson C.B. da; Abreu,Celina Monteiro; Cunha,Rodrigo Delvecchio da; Valadão,Ana Luiza Chaves; Santos,André Felipe dos; Tanuri,Amilcar. |
| Abstract Approximately 185 million people worldwide are chronically infected with hepatitis C virus (HCV). The first-wave of approved NS3 protease inhibitors (PIs) were Telaprevir and Boceprevir, which are currently discontinued. Simeprevir is a second-wave PI incorporated into the Brazilian hepatitis C treatment protocol. Drug resistance plays a key role in patients' treatment regimen. Here, we developed a simple phenotypic assay to evaluate the impact of resistance mutations in HCV NS3 protease to PIs, using a protein expression vector containing wild type NS3 protease domain and NS4A co-factor. We analyzed the impact of five resistance mutations (T54A, V36M, V158I, V170I and T54S+V170I) against Telaprevir, Boceprevir and Simeprevir. Protein... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Protease inhibitor; Phenotypic test; Hepatitis C virus; HCV NS3 protease; Resistance mutation. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000300358 |
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| Elsayeh,H; Abdallah,N; Hamed,NA; Morsi,MG; Eldighidy,A; Kamal,HA. |
| Several antibodies, including anticardiolipin antibodies (ACA), have been detected among chronically infected hepatitis C virus (HCV) patients. The present work aimed at ascertaining the clinical significance of ACA levels among HCV infection associated with two commonly encountered diseases, thrombocytopenia and arteriovenous-shunt malfunction. Six groups were studied, 11 HCV-positive thrombocytopenic patients (group I), 14 HCV-positive non-thrombocytopenic patients (group II) and 15 healthy controls (group III), 11 anti-HCV-positive hemodialysis patients with non-functioning shunt (group IV), 14 anti-HCV-positive hemodialysis patients with patent shunt (group V) (Bain Medical Equipment Co., China) and 15 healthy controls (group VI). Anticardiolipin... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C virus; Hemodialysis; Anticardiolipin antibody; Enzyme-linked immunosorbent assay. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400014 |
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| Henrique-Araújo,Ricardo; Quarantini,Lucas C.; Caribé,André C.; Argolo,Felipe C.; Jesus-Nunes,Ana Paula; Morais-de-Jesus,Mychelle; Dantas-Duarte,Adriana; Moreira,Tayne Miranda; Oliveira,Irismar Reis de. |
| Abstract Human T-cell lymphotropic virus type 1 (HTLV-1) has low prevalence rates, but is endemic in some regions of the world. It is usually a chronic asymptomatic infection, but it can be associated with serious neurologic and urinary conditions. Hepatitis C virus (HCV) is broadly spread out worldwide. The majority of these infections have a chronic course that may progress to cirrhosis and hepatocellular carcinoma. Objectives: To compare sociodemographic and mental health (risk behaviors, depression, and suicide) aspects, and quality of life among patients with HCV or HTLV-1. Methods: Observational, comparative and cross-sectional study involving outpatients with HCV or HLTV-1 infection. Sociodemographic characteristics, risk behaviors and quality of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C virus; Human T-cell lymphotropic virus type 1; Quality of life; Risk behaviors; Depression; Suicide. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400224 |
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| Reis,Francisco José Farias Borges dos; Sousa,Tiago Almeida de; Oliveira,Manoela S.; Dantas,Ney; Silveira,Martha; Braghiroly,Maria Ignês Freitas Melro; Paraná,Raymundo. |
| Recent studies have suggested that some patients with idiopathic dilated cardiomyopathy (IDC) are also afflicted with insidious forms of viral myocarditis. Participation of hepatitis C virus (HCV) in this process has been postulated. The objective of this study was to evaluate a possible association between hepatitis C virus and idiopathic dilated cardiomyopathy. Systematic review of the literature using electronic databases (MEDLINE, EMBASES, LILACS and COCHRANE) for the period from 1995 to 2005, limited to papers published in English, Spanish and Portuguese. Sixty-two papers were found, of which six were in accordance with the proposed methodology. After selection, the articles were classified by quality of data and number of variables studied. Most of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Idiopathic dilated cardiomyopathy; Hepatitis C virus; Systematic review. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300009 |
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| Costa,Luciano Bello; Ferraz,Maria Lucia Gomes; Perez,Renata M.; Ferreira,Adalgisa S.; Matos,Carla Adriana L.; Lanzoni,Valéria P.; Silva,Antônio Eduardo. |
| There is increasing interest in the identification of factors associated with liver disease progression in patients infected with hepatitis C virus (HCV). We assessed host-related factors associated with a histologically advanced stage of this disease and determined the rate of liver fibrosis progression in HCV-infected patients. We included patients submitted to liver biopsy, who were anti-HCV and HCV RNA positive, who showed a parenteral risk factor (blood transfusion or intravenous drug use), and who gave information about alcohol consumption.Patients were divided into two groups for analysis: group 1 - grades 0 to 2; group 2 - grades 3 to 4. The groups were compared in terms of sex, age at the time of infection, estimated duration of infection and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C virus; Liver fibrosis; Patients. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500002 |
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| Pavan,Maria Helena P.; Aoki,Francisco Hideo; Monteiro,Dinaida Teresa; Gonçales,Neiva Sellan L.; Escanhoela,Cecília Amélia F.; Gonçales Júnior,Fernando L.. |
| From 1992 to 1995 we studied 232 (69% male, 87% Caucasian) anti-human immunodeficiency virus (anti-HIV) positive Brazilian patients, through a questionnaire; HIV had been acquired sexually by 50%, from blood by 32%, sexually and/or from blood by 16.4% and by an unknown route by 1.7%. Intravenous drug use was reported by 29%; it was the most important risk factor for HIV transmission. The alanine aminotransferase quotient (qALT) was >1 for 40% of the patients, 93.6% had anti-hepatitis A virus antibody, 5.3% presented hepatitis B surface antigen, 44% were anti-hepatitis B core antigen positive and 53.8% were anti-hepatitis C virus (anti-HCV) positive. The anti-HCV test showed a significant association with qALT>1. Patients for whom the probable HIV... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C virus; Human immunodeficiency virus; Alanine aminotransferase quotient; Anti-hepatitis A antibody; Hepatitis B surface antigen; Anti-hepatitis B core antigen (anti-HBc). |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400005 |
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| Bricks,Guilherme; Senise,Jorge Figueiredo; Pott Junior,Henrique; Grandi,Giuliano; Passarini,Amanda; Caldeira,Débora Bellini; Carnaúba Junior,Dimas; Moraes,Hamilton Antonio Bonilha de; Granato,Celso Franscisco Hernandes; Castelo,Adauto. |
| ABSTRACT Background and aims: Hepatitis E virus infection in patients with underlying chronic liver disease is associated with liver decompensation and increased lethality. The seroprevalence of hepatitis E virus in patients with chronic hepatitis C in Brazil is unknown. This study aims to estimate the seroprevalence of hepatitis E virus in patients with chronic hepatitis C and to describe associated risk factors. Methods: A total of 618 patients chronically infected with hepatitis C virus from three reference centers of São Paulo, Brazil were included. Presence of anti-HEV IgG was assessed by enzyme-linked immunosorbent assay (WANTAI HEV-IgG ELISA). Results: Out of the 618 patients tested, 10.2% turned out positive for anti-HEV IgG (95% CI 8.0–12.8%).... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis E virus; Hepatitis C virus; Brazil; Seroprevalence. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200085 |
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| Galperim,Bruno; Mattos,Angelo A; Stein,Airton T; Schneider,Nuttiane C; Buriol,André; Fonseca,André; Lunge,Vagner; Ikuta,Nilo. |
| BACKGROUND: Hepatitis C virus (HCV) infection is the most common cause of acute or chronic hepatitis in patients on hemodialysis (HD). The purpose of this study was to describe the prevalence of positive HCV RNA and investigate injection drug use as an emerging risk factor in patients with chronic renal disease on HD. METHODS: This was a multicenter cross-sectional study with 325 patients with chronic renal disease on HD in the period between August 1, 2005 to August 30, 2006, receiving care at four institutions in the city of Porto Alegre, Southern Brazil. Epidemiological data were collected by means of a structured questionnaire. The following laboratory tests were performed: alanine aminotransferase (ALT), anti-hepatitis C virus antibodies (anti-HCV),... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Hepatitis C virus; Hemodialysis; Injection drug use; Risk factors. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400020 |
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| Fanpu,Ji; Zhang,Shu; Huang,Na; Deng,Hong; Li,Zongfang. |
| Patients with hepatitis C virus-related decompensated cirrhosis can benefit frominterferonbased antiviral therapy, but the common complication of cytopenia is a contraindication for this treatment. Splenectomy prior to interferon therapy may alleviate this problem. To investigate whether splenectomy improves the efficacy of antiviral therapy, 13 interferonnaïve hepatitis C virus decompensated cirrhotic patients underwent splenectomy between January 2008 and January 2011, followed 1-3 months later by an interferon-based therapeutic regimen (pegylated/standard interferon-α combined with ribavirin for 48 weeks). Ten (76.9%) of the patients developed postoperative complications, which included minor portal vein thrombosis (2/13, 15.4%) and transient ascites... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Hepatitis C virus; Thrombocytopenia; Splenectomy; Antiviral therapy. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500014 |
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| Lyra,Andre C.; Fan,Xiaofeng; Di Bisceglie,Adrian M.. |
| CD81 is a surface-associated protein expressed in the membranes of mammalian cells. It has been suggested that CD81 interacts with hepatitis C virus E2 protein, and thus might facilitate the entry of HCV into hepatocytes. The envelope-binding site appears to involve amino acids (aa) 480-493 and 544-551 within the E2 glycoprotein. Little is known about the quasispecies genetic diversity of these two regions. We studied four patients who underwent transplantation for HCV-related cirrhosis and who developed recurrent hepatitis C. We evaluated HCV quasispecies diversity in serum samples obtained at the time of transplantation and at several time points thereafter. Quasispecies diversity was assessed by cloning and sequencing of viral isolates, with computer... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C virus; CD81; Diversity. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200002 |
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| Bricks,Guilherme; Senise,Jorge Figueiredo; Pott-Jr,Henrique; Grandi,Giuliano; Carnaúba-Jr,Dimas; Moraes,Hamilton Antonio Bonilha de; Granato,Celso Franscisco Hernandes; Castelo,Adauto. |
| ABSTRACT Background: Hepatitis E virus (HEV) infection in patients with pre-existing liver disease has shown high morbidity and lethality. The consequences of HEV superinfection in patients with chronic hepatitis C virus (HCV) infection are not fully understood. This study aimed to evaluate the association between the presence of anti-HEV antibodies, liver cirrhosis, and insulin resistance. Methods: A total of 618 patients chronically infected with HCV were included from three reference centers for viral hepatitis in São Paulo, Brazil. Presence of anti-HEV IgG was assessed by enzyme-linked immunosorbent assay (WANTAI HEV-IgG ELISA). Results: The seroprevalence of anti-HEV in patients with cirrhosis was significantly higher than in patients without... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis E virus; Hepatitis C virus; Liver cirrhosis; Insulin resistance. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000100045 |
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| Andrade,Andreia Alves de; Silva,Ágabo Macêdo da Costa e; Carneiro,Megmar Aparecida dos Santos; Teles,Sheila Araújo; Martins,Regina Maria Bringel. |
| Abstract To assess the prevalence of hepatitis C virus infection among men who have sex with men (MSM) in Central Brazil, a cross-sectional study was conducted in the City of Goiânia, Central Brazil, using Respondent-Driven Sampling (RDS). All serum samples were tested for anti-HCV and also for alanine aminotransferase (ALT). Anti-HCV positive samples and/or those with elevated ALT were tested for HCV RNA and genotyped. Of the 522 participants, four were found to be anti-HCV positive, and one was also HCV RNA positive (active HCV infection). Elevated ALT was found in 14 individuals. Of these, one showed evidence of acute HCV infection (HCV RNA positive and anti-HCV negative). Therefore, five MSM were positive for either anti-HCV and/or HCV RNA, giving a... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Hepatitis C virus; Men who have sex with men; Prevalence; Brazil. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400271 |
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| Vigani,A.G.; Macedo-de-Oliveira,A.; Pavan,M.H.P.; Pedro,M.N.; Gonçales Jr.,F.L.. |
| Hepatitis C virus (HCV) is essentially hepatotropic but its manifestations can extend beyond the liver. It can be associated with autoimmune diseases, such as mixed cryoglobulinemia, membranoproliferative glomerulonephritis, autoimmune thyroiditis, and lymphoproliferative disorders. The mechanisms that trigger these manifestations are not completely understood. We describe a 48-year-old man with chronic HCV infection (circulating HCV RNA and moderate hepatitis as indicated by liver biopsy), cryoglobulinemia, and sensory and motor peripheral neuropathy. The diagnosis of multineuropathy was confirmed by clinical examination and electromyographic tests. A nerve biopsy revealed an inflammatory infiltrate in the perineurial space and signs of demyelination and... |
| Tipo: Info:eu-repo/semantics/report |
Palavras-chave: Hepatitis C virus; Neurological manifestations; Cryoglobulins; Interferon; Ribavirin. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200001 |
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| Carmo,R.A.; Oliveira,G.C.; Guimarães,M.D.C.; Oliveira,M.S.; Lima,A.A.; Buzek,S.C.; Corrêa-Oliveira,R.; Rocha,M.O.C.. |
| We determined and analyzed risk factors of hepatitis C virus (HCV)-infected Brazilian hemophiliacs according to their virological, clinical and epidemiological characteristics. A cross-sectional and retrospective study of 469 hemophiliacs was carried out at a Brazilian blood center starting in October 1997. The prevalence of HCV infection, HCV genotypes and factors associated with HCV RNA detection was determined. The seroprevalence of anti-HCV antibodies (ELISA-3.0) was 44.6% (209/469). Virological, clinical and epidemiological assessments were completed for 162 positive patients. There were seven (4.3%) anti-HCV seroconversions between October 1992 and October 1997. During the same period, 40.8% of the positive anti-HCV hemophiliacs had abnormal alanine... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C virus; HCV genotypes; Hemophilia; Chronic liver disease; Transfusion; Brazil. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500012 |
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| Registros recuperados: 29 | |
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