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Model of chromosome associations in Mus domesticus spermatocytes Biol. Res.
Berríos,Soledad; Manterola,Marcia; Prieto,Zulita; López-Fenner,Julio; Page,Jesús; Fernández-Donoso,Raúl.
Understanding the spatial organization of the chromosomes in meiotic nuclei is crucial to our knowledge of the genome's functional regulation, stability and evolution. This study examined the nuclear architecture of Mus domesticus 2n=40 pachytene spermatocytes, analyzing the associations among autosomal bivalents via their Centromere Telomere Complexes (CTC). The study developed a nuclear model in which each CTC was represented as a 3D computer object. The probability of a given combination of associations among CTC was estimated by simulating a random distribution of 19 indistinguishable CTC over n indistinguishable "cells" on the nuclear envelope. The estimated association frequencies resulting from this numerical approach were similar to those obtained...
Tipo: Journal article Palavras-chave: Bivalent associations; Nuclear model; Mouse spermatocytes; Heterochromatin distribution.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000300003
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