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Modulation of intercellular communication by differential regulation and heteromeric mixing of co-expressed connexins BJMBR
Beyer,E.C.; Gemel,J.; Seul,K.H.; Larson,D.M.; Banach,K.; Brink,P.R..
Intercellular communication may be regulated by the differential expression of subunit gap junction proteins (connexins) which form channels with differing gating and permeability properties. Endothelial cells express three different connexins (connexin37, connexin40, and connexin43) in vivo. To study the differential regulation of expression and synthesis of connexin37 and connexin43, we used cultured bovine aortic endothelial cells which contain these two connexins in vitro. RNA blots demonstrated discordant expression of these two connexins during growth to confluency. RNA blots and immunoblots showed that levels of these connexins were modulated by treatment of cultures with transforming growth factor-ß1. To examine the potential ability of these...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Endothelium; Heteromeric connexons; Intercellular communication; Connexin37; Connexin40.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400004
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