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| CARDINALI,V.C.B.; DIAS,A.C.R.; MUELLER,T.C.; ABERCROMBIE,L.; STEWART JR.,C.N.; TORNISIELO,V.L.; CHRISTOFFOLETI,P.J.. |
| In Brazil, few research works on mechanisms of weed resistance to glyphosate have been conducted so far. Therefore, this research aimed to study analytical procedures determining the relation between the concentration of plant shikimate after glyphosate application and the plant resistance to this herbicide; and evaluate the glyphosate absorption and translocation into two resistant ® and susceptible (S) horseweed biotypes to glyphosate. Horseweed plants with nine true leaves received glyphosate (720 g a.e. ha-1), and 2, 3, 4, 7 and 10 days after application (DAA) the concentration of shikimic acid was measured by HPLC. In another experiment, plants were treated with radiolabeled glyphosate (14C) (1.456 MBq mmol-1 specific activity) and radioactivity was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Conyza bonariensis; High Performance Liquid Chromatography; EPSPS; Selection; Radioactivity. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582015000100109 |
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| Xue,Hefei; Li,Yuzhong; Zhang,Wenjie; Lu,Dongrui; Chen,Yinghui; Yin,Jingjing; Meng,Yihan; Ying,Xixiang; Kang,Tingguo. |
| The aim of this study is to develop a simple and specific HPLC method using vitexin as the internal standard to investigate the pharmacokinetics of isoquercitrin (ISOQ) after three different doses administrated intravenously to rats. The pharmacokinetic parameters were calculated by both compartmental and non-compartmental approaches. The results showed that ISOQ fitted a three-compartment open model. The values of AUC increased proportionally within the range of 5-10 mg·kg-1. Moreover, a half-life, b half-life, ªCL, MRT0-t and MRT0→∞ of ISOQ in rats showed significant differences between 20 mg·kg-1 and other doses, indicating that ISOQ presented dose-dependent pharmacokinetics in the range of 5-10 mg·kg-1 and non-linear pharmacokinetics at... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Isoquercitrin/pharmacokinetics; Isoquercitrin/experimental study; High Performance Liquid Chromatography; Crataegus pinnatifida Bge; Var major/leaves; Var major/phytochemistry. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300005 |
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| Chiari-Andréo,Bruna Galdorfini; Trovatti,Eliane; Marto,Joana; Almeida-Cincotto,Maria Gabriela José de; Melero,Ana; Corrêa,Marcos Antonio; Chiavacci,Leila Aparecida; Ribeiro,Helena; Garrigues,Teresa; Isaac,Vera Lucia Borges. |
| ABSTRACT Guava (Psidium guajava L.) is a native fruit of the American tropics with commercial applications for its taste, flavor and aroma. Numerous pharmacological uses have been described for it, such as the antiseptic effect of its leaves, the use of the fresh fruit and tea from its leaves for the treatment of diarrhea, dysentery, diabetes mellitus, and others. However, considering its rich composition, the guava also is a potential source of antioxidants to be used in the development of new formulations for cosmetic and/or dermatological applications, the main focus of this research. Herein, we describe the study of the phytochemical composition and the antioxidant activity of a guava extract prepared with non-toxic solvents aiming its use at... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: P. guajava L./phytochemistry; P. guajava L./use in cosmetics; P. guajava L./antioxidant/chemical composition; P. guajava L/chemical stability; High Performance Liquid Chromatography. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200612 |
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| Çelebier,Mustafa; Kaynak,Mustafa Sinan; Altınöz,Sacide; Sahin,Selma. |
| A simple, rapid and reproducible HPLC method was developed for the simultaneous determination of amlodipine and valsartan in their combined dosage forms, and for drug dissolution studies. A C18 column (ODS 2, 10 μm, 200 x 4.6 mm) and a mobile phase of phosphate buffer (pH 3.6 , 0.01 mol L-1):acetonitrile: methanol (46:44:10 v/v/v) mixture were used for separation and quantification. Analyses were run at a flow-rate of 1 mL min-1 and at ambient temperature. The injection volume was 20 μL and the ultraviolet detector was set at 240 nm. Under these conditions, amlodipine and valsartan were eluted at 7.1 min and 3.4 min, respectively. Total run time was shorter than 9 min. The developed method was validated according to the literature and found to be linear... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amlodipine besylate; Valsartan; High Performance Liquid Chromatography; Method Development; Validation; Dissolution Study. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000400018 |
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| Santos,Carolina Alves dos; Mazzola,Priscila Gava; Polacwiecz,Bronislaw; Knirsch,Marcos Camargo; Cholewa,Olívia; Penna,Thereza Christina Vessoni. |
| Parenteral solutions (PS) are one of the most commonly used drug delivery vehicles. Interactions among the drug, components in the drug's formulation, and the PS can result in the formation of inactive complexes that limit efficacy or increase side effects. The aim of this work was to evaluate possible interactions between the drugs and PS, assess drug stability and to identify degradation products after 20 h at room temperature. Furosemide (FSM) and Aminophylline (APN) were added to PS containing either 20% mannitol or 0.9% NaCl at pH 6.5-7.5 and 10-11. Their behavior was studied individually and as an admixture, after 1 h oxidation with H2O2, using a spectrophotometer and HPLC. Individually, FSM and APN added to 20% mannitol and 0.9% NaCl solutions had... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Parenteral solutions; Spectrophotometer; High Performance Liquid Chromatography; Furosemide; Aminophylline. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100011 |
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