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Coexistence of potentiation and fatigue in skeletal muscle BJMBR
Rassier,D.E.; MacIntosh,B.R..
Twitch potentiation and fatigue in skeletal muscle are two conditions in which force production is affected by the stimulation history. Twitch potentiation is the increase in the twitch active force observed after a tetanic contraction or during and following low-frequency stimulation. There is evidence that the mechanism responsible for potentiation is phosphorylation of the regulatory light chains of myosin, a Ca2+-dependent process. Fatigue is the force decrease observed after a period of repeated muscle stimulation. Fatigue has also been associated with a Ca2+-related mechanism: decreased peak Ca2+ concentration in the myoplasm is observed during fatigue. This decrease is probably due to an inhibition of Ca2+ release from the sarcoplasmic reticulum....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Posttetanic potentiation; Staircase; High-frequency fatigue; Low-frequency fatigue; Ca2+ sensitivity; RLC phosphorylation; Myosin light chains.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000500003
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