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Role of α2-adrenoceptors in the lateral parabrachial nucleus in the control of body fluid homeostasis BJMBR
Andrade,C.A.F.; Andrade-Franzé,G.M.F.; De Paula,P.M.; De Luca Jr.,L.A.; Menani,J.V..
Central α2-adrenoceptors and the pontine lateral parabrachial nucleus (LPBN) are involved in the control of sodium and water intake. Bilateral injections of moxonidine (α2-adrenergic/imidazoline receptor agonist) or noradrenaline into the LPBN strongly increases 0.3 M NaCl intake induced by a combined treatment of furosemide plus captopril. Injection of moxonidine into the LPBN also increases hypertonic NaCl and water intake and reduces oxytocin secretion, urinary sodium, and water excreted by cell-dehydrated rats, causing a positive sodium and water balance, which suggests that moxonidine injected into the LPBN deactivates mechanisms that restrain body fluid volume expansion. Pretreatment with specific α2-adrenoceptor antagonists injected into the LPBN...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Parabrachial nucleus; Sodium; Natriuresis; Thirst; Hindbrain; Taste.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000100011
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Lesions of the commissural subnucleus of the nucleus of the solitary tract increase isoproterenol-induced water intake BJMBR
Blanch,G.T.; Freiria-Oliveira,A.H.; Colombari,E.; Menani,J.V.; Colombari,D.S.A..
The nucleus of the solitary tract (NTS) is the primary site of the cardiovascular afferent information about arterial blood pressure and volume. The NTS projects to areas in the central nervous system involved in cardiovascular regulation and hydroelectrolyte balance, such as the anteroventral third ventricle region and the lateral parabrachial nucleus. The aim of the present study was to investigate the effects of electrolytic lesion of the commissural NTS on water and 0.3 M NaCl intake and the cardiovascular responses to subcutaneous injection of isoproterenol. Male Holtzman rats weighing 280 to 320 g were submitted to sham lesion or electrolytic lesion of the commissural NTS (N = 6-15/group). The sham-lesioned rats had the electrode placed along the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nucleus of the solitary tract; Commissural nucleus of the rat solitary tract; Water intake; Arterial pressure; Isoproterenol; Hindbrain.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000800013
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