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Evaluation of hela cell lineage response to β radiation from Holmium-166 embedded in ceramic seeds BABT
Valente,Eduardo Sarmento; Cuperschmid,Ethel Mizrahy; Campos,Tarcisio Passos Ribeiro de.
This work studied the effects of β radiation of Ho-166 embedded in ceramic seeds on HeLa cells. Methodology consisted in the production of ceramic seeds with holmium-165 by sol-gel route. Chemical and physical characterizations of the seeds were performed. Subsequently, nuclear characterization was performed by gamma spectrometry. Experimental and theoretical activities were defined and initial dose rate were evaluated by MIRD (Medical Internal Radiation Dose Committee) methodology. The seeds were placed in confluent culture flasks and remained for six radionuclide half-lives. Biological results were represented by a clean 6 mm diameter area around the seed where the tumour cells were killed. The initial dose rate was 15.5 Gy. h-1. The maximum absorbed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Brachytherapy; Ceramic seeds; Holmium; Cancer control; HeLa cells.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500013
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