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	Provedor de dados BJMBR (3) Autor Carvalho,E.M. (2) Almeida,R.P. (1) Bacellar,O. (1) Barral,A. (1) Barral-Netto,M. (1) Bertho,A.L. (1) Brodskyn,C. (1) Coutinho,S.G. (1) Da-Cruz,A.M. (1) Lessa,H. (1) Ribeiro-de-Jesus,A. (1) Santiago,M.A. (1) Mais... Palavra-chave Human leishmaniasis (3) Cytokines (2) Apoptosis (1) Cell death (1) Flow cytometry (1) IL-10 (1) IL-12 (1) Immunological responses (1) Immunoregulation (1) Leishmaniasis (1) Pathology (1) T cells (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2000 (1) 1998 (2) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Human_Leishmaniasis@cytokines.bahia.br BJMBR Barral-Netto,M.; Brodskyn,C.; Carvalho,E.M.; Barral,A.. The cell-mediated immune response is critical in the resistance to and recovery from leishmaniasis. Cytokines are central elements in mounting an immune response and have received a great deal of attention in both human and experimental leishmaniasis. IFN-<FONT FACE="Symbol">g</font> is responsible for macrophage activation leading to leishmanicidal mechanisms. Understanding the balance of cytokines that lead to enhanced production of or synergize with IFN-<FONT FACE="Symbol">g</font>, and those cytokines that counterbalance its effects is fundamental for developing rational immunotherapeutic or immunoprophylactic approaches to leishmaniasis. Here we focus on the cytokine balance in human leishmaniasis, particularly IL-10 as an... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cytokines; Human leishmaniasis; Immunoregulation; IL-12; IL-10. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100021 Cytokine profile and pathology in human leishmaniasis BJMBR Ribeiro-de-Jesus,A.; Almeida,R.P.; Lessa,H.; Bacellar,O.; Carvalho,E.M.. The clinical spectrum of leishmaniasis and control of the infection are influenced by the parasite-host relationship. The role of cellular immune responses of the Th1 type in the protection against disease in experimental and human leishmaniasis is well established. In humans, production of IFN-<FONT FACE="Symbol">g</font> is associated with the control of infection in children infected by Leishmania chagasi. In visceral leishmaniasis, an impairment in IFN-<FONT FACE="Symbol">g</font> production and high IL-4 and IL-10 levels (Th2 cytokines) are observed in antigen-stimulated peripheral blood mononuclear cells (PBMC). Moreover, IL-12 restores IFN-<FONT FACE="Symbol">g</font> production and enhances the cytotoxic... Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmaniasis; Human leishmaniasis; Cytokines; Pathology; Immunological responses. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100020 Detection of early apoptosis and cell death in T CD4+ and CD8+ cells from lesions of patients with localized cutaneous leishmaniasis BJMBR Bertho,A.L.; Santiago,M.A.; Da-Cruz,A.M.; Coutinho,S.G.. Human localized cutaneous leishmaniasis (LCL), induced by Leishmania braziliensis, ranges from a clinically mild, self-healing disease with localized cutaneous lesions to severe forms which can present secondary metastatic lesions. The T cell-mediated immune response is extremely important to define the outcome of the disease; however, the underlying mechanisms involved are not fully understood. A flow cytometric analysis of incorporation of 7-amino actinomycin D and CD4+ or CD8+ T cell surface phenotyping was used to determine whether different frequencies of early apoptosis or accidental cell death occur at different stages of LCL lesions. When all cells obtained from a biopsy sample were analyzed, larger numbers of early apoptotic and dead cells were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Apoptosis; Flow cytometry; Human leishmaniasis; Cell death; T cells. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000300010 Registros recuperados: 3 Primeira ... 1 ... Última

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