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Recovery of drug residues in equipment and utensils used by compounding pharmacies after standard cleaning procedure BJPS
Prioste,Tassia; Magon,Thiago Ferreira dos Santos; Fagundes,Vinicius; Montanha,Maiara Camotti; Moriwaki,Cristiane; Kimura,Elza.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Compounding pharmacy/cleaning procedure/equipments; Pharmacy equipaments/cleaning; Pharmaceutical products/contamination; Captopril; Acetylsalicylic acid; Hydrochlorothiazide.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000200317
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Simultaneous determination of candesartan and hydrochlorothiazide in human plasma by LC-MS/MS BJPS
Bonthu,Mohan Gandhi; Atmakuri,Lakshmana Rao; Jangala,Venkateswara Rao.
Abstract A simple, sensitive, rapid and highly efficient LC-MS/MS method was developed for the determination of Candesartan and Hydrochlorothiazide simultaneously in human plasma. The method employed Zorbax eclipse C18 (150 X 4.6 mm, 5µ) column using acetate buffer: acetonitrile (25:75%, v/v) as the mobile phase. The mobile phase flow rate is 1 mL/min which was delivered into the mass spectrometer electron spray ionization chamber. The Liquid/liquid extraction procedure was used in the method for the extraction of analytes. The chromatograph was attached to a negative ion mode tandem mass spectrometer and the method was validated for all the parameters as per the guidelines of US-FDA. The ions were detected in multiple reaction monitoring mode and the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Candesartan; Hydrochlorothiazide; LC-MS/MS; Method validation; Human plasma..
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100625
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Continuous wavelet transform methods for the simultaneous determinations and dissolution profiles of valsartan and hydrochlorothiazide in tablets BJPS
Dinç,Erdal; Üstündağ,Özgür; Tilkan,Günseli Yüksel; Türkmen,Berna; Özdemir,Nurten.
ABSTRACT Continuous wavelet transform (CWT) was proposed for the simultaneous determination and dissolution profiles of valsartan (VAL) and hydrochlorothiazide (HCT) in tablets, without the use of a chemical separation procedure. The CWT approach was applied to the original UV spectra and their ratio spectra in the optimal wavelength ranges. After testing several wavelet families, Mexican hat function-CWT and Daubechies7-CWT (mexh-CWT and db7-CWT, respectively) were found to be suitable for the transformation of the original UV spectra. In the following procedure, mexh-CWT and Coiflets3-CWT (coif3-CWT) were found to be appropriate for the signal analysis of ratio spectra (RS) of VAL/HCT and HCT/VAL. Calibration graphs for VAL and HCT were obtained by...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Spectral Continuous Wavelets Transform; Valsartan; Hydrochlorothiazide; Binary mixture/tablets..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100618
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