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	Provedor de dados BJPS (2) Autor Ansari,Khalid Akhter (1) Anwar,Shoeb (1) Garcia,Jerusa Simone (1) Júlio,Tamíris Amanda (1) Pagar,Kunal Pratap (1) Trevisan,Marcello Garcia (1) Vavia,Pradeep Ratilal (1) Zâmara,Igor Fernando (1) Mais... Palavra-chave Hypertension/treatment (2) Chronotherapeutics/hypertension treatment (1) Differential Scanning Calorimetry/drug analysis (1) Drugs/controlled release (1) Ethyl cellulose/drugs coated (1) Felodipine/chronotherapeutic application (1) Felodipine/self-microemulsifying delivery (1) High performance liquid chromatography/quantitative analysis (1) Pharmaceutical formulations/quantitative analysis.. (1) Self-microemulsifying drug delivery system/development (1) Valsartan/compatibility (1) Valsartan/stability (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2014 (1) 2013 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Design and optimization of self-microemulsifying drug delivery system (SMEDDS) of felodipine for chronotherapeutic application BJPS Ansari,Khalid Akhter; Pagar,Kunal Pratap; Anwar,Shoeb; Vavia,Pradeep Ratilal. The objective of this research work was to design, develop and optimize the self micro-emulsifying drug delivery system (SMEDDS) of Felodipine (FL) filled in hard gelatine capsule coated with polymer in order to achieve rapid drug release after a desired time lag in the management of hypertension. Microemulsion is composed of a FL, Lauroglycol FCC, Transcutol P and Cremophor EL. The optimum surfactant to co-surfactant ratio was found to be 2:1. The resultant microemulsions have a particle size in the range of 65-85 nm and zeta potential value of -13.71 mV. FL release was adequately adjusted by using pH independent polymer i.e. ethyl cellulose along with dibutyl phthalate as plasticizer. Influence of formulation variables like viscosity of polymer, type of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Felodipine/self-microemulsifying delivery; Felodipine/chronotherapeutic application; Self-microemulsifying drug delivery system/development; Drugs/controlled release; Ethyl cellulose/drugs coated; Hypertension/treatment; Chronotherapeutics/hypertension treatment. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100021 Compatibility and stability of valsartan in a solid pharmaceutical formulation BJPS Júlio,Tamíris Amanda; Zâmara,Igor Fernando; Garcia,Jerusa Simone; Trevisan,Marcello Garcia. Valsartan (VAL) is a highly selective blocker of the angiotensin II receptor that has been widely used in the treatment of hypertension. Active pharmaceutical ingredient compatibility with excipients (crospovidone, hypromellose, magnesium stearate, microcrystalline cellulose and titanium dioxide) is usually evaluated in solid pharmaceutical development. Compatibility and stability can be evaluated by liquid chromatography. Studies were performed using binary mixtures of 1:1 (w/w) VAL/excipient; samples were stored under accelerated stability test conditions (40 ºC at 75% relative humidity). The results indicate that VAL is incompatible with crospovidone and hypromellose, which reduced the VAL content and gave rise to new peaks in the chromatogram due to... Tipo: Info:eu-repo/semantics/article Palavras-chave: Valsartan/compatibility; Valsartan/stability; Hypertension/treatment; Differential Scanning Calorimetry/drug analysis; High performance liquid chromatography/quantitative analysis; Pharmaceutical formulations/quantitative analysis... Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000400003 Registros recuperados: 2 Primeira ... 1 ... Última

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