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| Jin,H; Haicheng,Y; Caiyun,Z; Yong,Z; Jinrong,W. |
| ABSTRACT Chicken coccidiosis is a parasitic disease caused by one or more species of Eimeria infection with severe consequences. The NF-κB signaling pathway and TGF-β4 play an important role in the inflammation and immune response caused by coccidiosis infection. This study was designed to investigate the changes of NF-κB signaling pathway and the effects of TGF-β4 silencing on the expression of NF-κB signaling pathway in chicken’s intestinal epithelial cells (IECs) after infecting with E. tenella sporozoites. TGF-β4 small interfering RNA (TGF-β4 siRNA) sequences were transfected into chicken IECs for reducing TGF-β4 expression. The results showed that compared with uninfected control group (Con.), the proinflammatory factors of NF-κB, IL-6, IL-2, IL-1β... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: NF-κB signaling pathway; TGF-β4; IECs; Coccidiosis; Chicken. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2020000400314 |
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