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The anti-IRBP IgG1 and IgG2a response does not correlate with susceptibility to experimental autoimmune uveitis BJMBR
Vieira de Moraes,L.; Martins,G.A.; Flangini,M.; Ibañez,O.M.; Sant'Anna,O.A.; Rizzo,L.V..
Susceptibility to experimental autoimmune uveitis (EAU) in inbred mice has been associated with a dominant Th1 response. Elevated anti-inter-photoreceptor retinoid-binding protein (anti-IRBP) IgG2a/IgG1 antibody ratios have been implicated as candidate markers to predict disease severity. In the present study, both the anti-IRBP antibody isotype and severity of EAU phenotypes were examined in 4 non-isogenic genetically selected mouse lines to determine if they can be used as general markers of disease. Mice between 8 and 12 weeks old selected for high (H III) or low (L III) antibody response and for maximum (AIR MAX) or minimum (AIR MIN) acute inflammatory reaction (AIR) were immunized with IRBP. Each experiment was performed with at least 5 mice per...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Autoimmunity; IgG1 and IgG2a isotypes; Inflammation; Genetically selected mice; Uveitis.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000600010
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