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	Provedor de dados BJPS (1) Autor I-Ching,Lee (1) Jesus,Caroline Regina de (1) Neiva,Teresinha de Jesus Carvalho (1) Vituri,Cidônia de Lourdes (1) Palavra-chave Bone marrow/biopsies (1) Chronic myeloid leukemia/treatment (1) Fibrosis (1) Imatinib mesylate/effectiveness (1) Imatinib mesylate/leukemia treatment (1) Vascularization (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2011 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Assessment of fibrosis and vascularization of bone marrow stroma of chronic myeloid Leukemia patients treated with imatinib mesylate and their relationship with the cytogenetic response BJPS Jesus,Caroline Regina de; I-Ching,Lee; Neiva,Teresinha de Jesus Carvalho; Vituri,Cidônia de Lourdes. Chronic Myeloid Leukemia (CML) is a myeloproliferative disease characterized by the presence of the Philadelphia chromosome (translocation between chromosomes 9 and 22), resulting in the formation of the hybrid BCR-ABL protein. Currently, the treatment of CML patients is performed with imatinib mesylate (IM), which promotes the elimination of leukemic cells by inhibiting the kinase activity of BCR-ABL. This study evaluated the effectiveness of IM by monitoring 22 CML patients in a chronic phase treated at the CEPON/SC with IM for a minimum follow-up period of two years. Cytogenetic Response (CR) and bone marrow biopsies (BMB) were evaluated before and after IM treatment. BMB were evaluated by detection of reticulin degree and vascularization. The results... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic myeloid leukemia/treatment; Imatinib mesylate/effectiveness; Imatinib mesylate/leukemia treatment; Bone marrow/biopsies; Fibrosis; Vascularization. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200012 Registros recuperados: 1 Primeira ... 1 ... Última

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