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Saccharomyces boulardii modulates and improves the immune response to Bovine Herpesvirus type 5 Vaccine Arq. Bras. Med. Vet. Zootec.
Roos,T.B.; Avila,L.F.C.; Sturbelle,R.T.; Leite,F.L.L.; Fischer,G.; Leite,F.P.L..
ABSTRACT There have been significant efforts towards the development of more efficient vaccines for animal health. A strategy that may be used to improve vaccine efficacy is the use of probiotics to enhance the immune response of the host, leading to increased immunogenicity of antigen preparations. Bovine herpesvirus 5 (BoHV-5) is an example of an important animal pathogen for which vaccines have provided only limited protection. In this study, we examined the use of the probiotic Saccharomyces boulardii (Sb) as a potential adjuvant to improve vaccine efficiency. We found that the supplemented animals exhibited an enhanced systemic IgG antibody response toward a Th1 response in favor of IgG2a and increased mRNA expression levels of the cytokines IFN-y,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Immune modulation; Probiotic; Cytokines; Vaccine.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000200375
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Classical and recent advances in the treatment of inflammatory bowel diseases BJMBR
Sales-Campos,H.; Basso,P.J.; Alves,V.B.F.; Fonseca,M.T.C.; Bonfá,G.; Nardini,V.; Cardoso,C.R.B..
Crohn's disease (CD) and ulcerative colitis (UC) are intestinal disorders that comprise the inflammatory bowel diseases (IBD). These disorders have a significant effect on the quality of life of affected patients and the increasing number of IBD cases worldwide is a growing concern. Because of the overall burden of IBD and its multifactorial etiology, efforts have been made to improve the medical management of these inflammatory conditions. The classical therapeutic strategies aim to control the exacerbated host immune response with aminosalicylates, antibiotics, corticosteroids, thiopurines, methotrexate and anti-tumor necrosis factor (TNF) biological agents. Although successful in the treatment of several CD or UC conditions, these drugs have limited...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Treatment; Immune modulation; Cellular therapy.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000200096
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Production optimization and characterization of immunomodulatory peptides obtained from fermented goat placenta Ciênc. Tecnol. Aliment.
Hou,Yinchen; Liu,Wangwang; Cheng,Yongxia; Zhou,Jiejing; Wu,Li; Yang,Gongming.
The goat placental immunomodulatory peptides were produced by fermentation with Aspergillus Niger. The objective of the present study was to investigate the effects of fermentation parameters (carbon source content, pH, and time) on spleen lymphocyte proliferation for the highest immune activity of the fermentation broth using response surface methodology (RSM). According to the data analysis by the Design-Expert® software, the stimulation index value (23.51%), which is the maximum immune activity, was obtained under the following conditions: content of carbon source 1.97 g·L-1, initial pH 5.0, and 74.43 h of fermentation time. Under the optimized fermentation conditions, at a certain concentration range, the fermentation broth produced a significant...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aspergillus Niger; Goat placenta; Immune modulation; Antioxidant; Bioactive peptide..
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612014000400012
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Partial chemical and functional characterization of milk whey products obtained by different processes Ciênc. Tecnol. Aliment.
Ziegler,Fabiane La Flor; Castro,Georgia Alvares; Moreno,Yara Maria Franco; Oya,Vanessa; Vilela,Maria Marluce dos Santos; Sgarbieri,Valdemiro Carlos.
Whey protein samples (S-1 to S-5) were tested in vivo and in vitro for nutritional properties and selected bioactivities. Weanling male Wistar rats fed modified AIN-93G (12 g protein.100 g-1) diets for 21 days were used the in vivo studies. The nutritional parameters did not differ among the protein diets tested. Erythrocyte glutathione content was considered high and was higher for S-3, but liver glutathione was the same for all dietary groups. For S-3, cytokine secretion (IL-10 and TNF-α) by human peripheral blood mononuclear cells (in RPMI-1640 medium) was higher in the absence of antigen than in the presence of BCG antigen. Interleukin-4 secretion was repressed in all treatments. The IC50, whey protein concentration required to inhibit 50% of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Whey proteins; Nutritive value; Immune modulation; Glutathione; Cytokines.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612012000100009
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