Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BJMBR (1) BJPS (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Rev. Bras. Ciênc. Avic. (1) Autor Chang,SC (1) Conserva,Geanne A. Alves (1) Costa-Silva,Thais A. da (1) Dai,F. (1) Dong,S.W. (1) Galisteo Jr,Andrés J. (1) Javeed,Aqeel (1) Lago,João Henrique G. (1) Lee,MT (1) Lee,TT (1) Lin,LJ (1) Lin,WC (1) Majeed,Arfa (1) Mushtaq,Muhammad Hassan (1) Omer,Muhammad Ovais (1) Sattar,Adeel (1) Sun,D. (1) Tempone,Andre G. (1) Xu,J.Z. (1) Zhang,F. (1) Mais... Palavra-chave Immunomodulatory (4) Antileishmanial (1) Bone tissue engineering (1) CTLA4 (1) Cell-mediated (1) Humoral (1) Immune response (1) In vitro (1) Laetiporussulphureus (1) Leishmania (L.) infantum chagasi (1) Lomefloxacin (1) Mesenchymal stem cells (1) Nectandra oppositifolia (1) Secosubamolide (1) Solid-state fermentation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Ano 2020 (1) 2019 (2) 2015 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Antileishmanial activity and immunomodulatory effect of secosubamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae) J. Venom. Anim. Toxins incl. Trop. Dis. Costa-Silva,Thais A. da; Conserva,Geanne A. Alves; Galisteo Jr,Andrés J.; Tempone,Andre G.; Lago,João Henrique G.. Abstract Background: Visceral leishmaniasis is a complex neglected tropical disease caused by Leishmania donovani complex. Its current treatment reveals strong limitations, especially high toxicity. In this context, natural products are important sources of new drug alternatives for VL therapy. Therefore, the antileishmanial and immunomodulatory activity of compounds isolated from Nectandra oppositifolia (Lauraceae) was investigated herein. Methods: The n-hexane extract from twigs of N. oppositifolia were subjected to HPLC/HRESIMS and bioactivity-guided fractionation to afford compounds 1 and 2 which were evaluated in vitro against Leishmania (L.) infantum chagasi and NCTC cells. Results: The n-hexane extract displayed activity against L. (L.) infantum... Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmania (L.) infantum chagasi; Antileishmanial; Nectandra oppositifolia; Secosubamolide; Immunomodulatory. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100317 Immunomodulation Properties of Solid-State Fermented Laetiporussulphureus Ethanol Extracts in Chicken Peripheral Blood Monocytes In Vitro Rev. Bras. Ciênc. Avic. Lin,WC; Lee,MT; Lin,LJ; Chang,SC; Lee,TT. ABSTRACT Laetiporus sp. is recognized as a fungal species traditionally used for medicinal purposes. This study investigated the in-vitro effects of solid-state fermented Laetiporussulphureus ethanol extracts (LSE) for their immunomodulatory potential. Bioactive levels detected in the LSE on different days throughout the fermentation period revealed that the 12th day was the most efficient, with 7.19 ± 0.66 GAE/g DM crude phenolic content, 2.71 ± 0.03 UAE/g DM crude triterpenoid content, 12.93 ± 0.88 GCE/g DM crude polysaccharides, and 96.44 ± 0.2 mg/g DM ergosterol content. In-vitroLSE tests on chPBMC showed no cytotoxicity within a range of 0.05-1 mg/mL, but LPS-inhibited cell viability was improved, as well as LPS-induced nitric oxide (NO) production... Tipo: Info:eu-repo/semantics/article Palavras-chave: Laetiporussulphureus; In vitro; Immunomodulatory; Solid-state fermentation. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2019000400316 CTLA4 enhances the osteogenic differentiation of allogeneic human mesenchymal stem cells in a model of immune activation BJMBR Dai,F.; Zhang,F.; Sun,D.; Zhang,Z.H.; Dong,S.W.; Xu,J.Z.. Allogeneic mesenchymal stem cells (allo-MSCs) have recently garnered increasing interest for their broad clinical therapy applications. Despite this, many studies have shown that allo-MSCs are associated with a high rate of graft rejection unless immunosuppressive therapy is administered to control allo-immune responses. Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) is a co-inhibitory molecule expressed on T cells that mediates the inhibition of T-cell function. Here, we investigated the osteogenic differentiation potency of allo-MSCs in an activated immune system that mimics the in vivo allo-MSC grafting microenvironment and explored the immunomodulatory role of the helper T cell receptor CTLA4 in this process. We found that MSC osteogenic... Tipo: Info:eu-repo/semantics/article Palavras-chave: CTLA4; Mesenchymal stem cells; Immunomodulatory; Bone tissue engineering. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000700629 Evaluation of immunomodulatory effects of lomefloxacin in mice BJPS Majeed,Arfa; Javeed,Aqeel; Omer,Muhammad Ovais; Mushtaq,Muhammad Hassan; Sattar,Adeel. Lomefloxacin is a flouroquinolone antibiotic that is quite efficacious against many gram negative and gram positive pathogens. Lomefloxacin evince antibacterial effects by modifying DNA gyrase in gram negative pathogens and topoisomerase IV in gram positive pathogens. This study is designed to assess the immunomodulatory effects of lomefloxacin in male albino mice. Three doses of lomefloxacin 12.5 mg/kg, 25 mg/kg and 50 mg/kg were used and delayed type hypersensitivity assay, cyclophosphamide induced neutropenic assay, carbon clearance assay, heamagglutination assay and mice lethality test were performed to evaluate the effects of lomefloxacin on immune system of mice. DTH assay has depicted the significant immunosuppressant potential of lomefloxacin at 25... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cell-mediated; Humoral; Immunomodulatory; Immune response; Lomefloxacin. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100628 Registros recuperados: 4 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco