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| Delgado Filho,V.S.; Lopes,P.F.I.; Podratz,P.L.; Graceli,J.B.. |
| Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tributyltin; Triphenyltin; Endocrine disruptor; Aromatase; Imposex; Mammalian reproductive organs. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900018 |
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| Lahbib, Youssef; Abidli, Sami; Chiffoleau, Jean-francois; Averty, Bernard; El Menif, Najoua Trigui. |
| We have assessed for the first time the current status of tributyltin (TBT) contamination in Hexaplex trunculus along Tunisian coastal waters. Two sampling campaigns have been performed in July 2004 and July 2007 at seven different sites. The snails were analyzed for imposex status, i.e. Imposex incidence, Relative Penis Length Index (RPLI) and Vas Deferens Sequence Index (VDSI), followed by the quantification of butyltins in their tissues. Imposex was detected in six populations from the 2004 samples and in five populations from the 2007 samples. The imposex incidence ranged from 0 (no imposex) to 100%, the RPLI from 0 to 56.7 and the VDSI from 0 to 4.4. TBT was also detected in six populations in 2004 and five populations in 2007. The concentrations... |
| Tipo: Text |
Palavras-chave: Tunisia; Imposex; Hexaplex trunculus; TBT; Tributyltin. |
| Ano: 2009 |
URL: http://archimer.ifremer.fr/doc/2009/publication-6499.pdf |
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| Fernandez-castro, Nora; His, Edouard; Cantin, Christian. |
| The Bay of Arcachon has been particularly affected by the impact of organotin-based antifouling paints (His, 1996). Boring gastropods, Ocenebra erinacea, have completely disappeared from the Bay, because of the castration induced by these compounds, from 1980 to 1990. There have been no studies on imposex effects in the Bay of Arcachon since the investigations of Poli (1972) who first described the phenomenon, and of Féral (1982) who attributed it to TBT. Recently, Sarradin & al. (1991) demonstrated the persistence of TBT and its degradation products in the sediments of the Bay, the latter being a potential source of pollution; Stroben & al. ( 1995) have conceived a contamination scale based on the VDSI (Vas Deferens Sequence Index) in prosobranch... |
| Tipo: Text |
Palavras-chave: Bassin d'Arcachon; Imposex; Ocenebra erinacea; TBT; Bay of Arcachon; Imposex; Ocenebra erinacea; TBT. |
| Ano: 1996 |
URL: http://archimer.ifremer.fr/doc/00038/14898/12224.pdf |
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