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Role of bradykinin in postprandial hypotension in humans BJMBR
Tumilero,S.; Gallo Jr.,L.; Foss,M.C.; Gouveia,L.M.F.; Reis,M.L.; Rothschild,A.M..
A transient significant decrease in mean arterial blood pressure (MAP) from 107 ± 3 to 98 ± 3 mmHg (P<0.05) was observed in elderly (59-69 years of age), healthy volunteers 25-30 min following ingestion of a test meal. In young volunteers (22-34 years of age), a postprandial decrease of MAP from 88 ± 3 to 83 ± 4 mmHg was also noted but it was not statistically significant. A 40% decrease in bradykinin (BK) content of circulatory high molecular weight kininogen had previously been observed in human subjects given the same test meal. We presently demonstrate by specific ELISA that the stable pentapeptide metabolite (1-5 BK) of BK increases from 2.5 ± 1.0 to 11.0 ± 2.5 pg/ml plasma (P<0.05) in elderly volunteers and from 2.0 ± 1.0 to 10.3 ± 3.2...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bradykinin; Postprandial hypotension; Indocyanine green; Captopril; 1-5 bradykinin.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000600015
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