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| Registros recuperados: 12 | |
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| Vendramini,Alex Augusto; Lábio,Roger Willian de; Rasmussen,Lucas Trevizani; Reis,Nathali Mattiuzo dos; Minett,Thais; Bertolucci,Paulo Henrique Ferreira; Pinhel,Marcela Augusta de Souza; Souza,Dorotéia Rossi Silva; Mazzotti,Diego Robles; Smith,Marília de Arruda Cardoso; Payão,Spencer Luiz Marques. |
| An inflammatory process has been involved in numerous neurodegenerative disorders such as Parkinson's disease, stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located in the vicinity of amyloid plaques. Cytokines, such as interleukin-8 (IL-8) and interleukin-1α (IL-1α), have been clearly involved in this inflammatory process. Polymorphisms of several interleukin genes have been correlated to the risk of developing AD. The present study investigated the association of AD with polymorphisms IL-8 -251T > A (rs4073) and IL-1α-889C > T (rs1800587) and the interactive effect of both, adjusted by the Apolipoprotein E genotype. 199 blood samples from patients with AD, 146 healthy elderly controls and 95 healthy young... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: IL-8; IL-1α; Alzheimer's Disease; APOE; Inflammatory response. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100001 |
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| Vignier, Julien; Rolton, Anne; Soudant, Philippe; Chu, Fu-lin E.; Robert, Rene; Volety, Aswani K.. |
| The 2010 explosion of the Deepwater Horizon (DWH) oil rig generated the largest marine oil spill in US history with millions of barrels of crude oil released in the Gulf of Mexico (GoM). The eastern oyster, Crassostrea virginica, is an ecologically and economically important species in the northern GoM. Due to its biological characteristics (sessile, filter feeding), juvenile oysters may have been affected. This study investigated the effects of surface-collected DWH oil prepared as high-energy water-accommodated fraction (HEWAF) on the survival of 2-month-old oyster spat, and evaluated the potential impacts of HEWAF on particle clearance rate and spat tissue. Exposure of oysters to a range of oil/HEWAF (0-7-66-147-908-3450 mu g tPAH50 (sum of 50... |
| Tipo: Text |
Palavras-chave: Oyster spat; Deepwater Horizon oil; Sublethal; Tissue; Inflammatory response; Histopathology. |
| Ano: 2018 |
URL: https://archimer.ifremer.fr/doc/00425/53615/54548.pdf |
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| Campos,Fabiana V.; Menezes,Thiago N.; Malacarne,Pedro F.; Costa,Fábio L. S.; Naumann,Gustavo B.; Gomes,Helena L.; Figueiredo,Suely G.. |
| Abstract The most poisonous fish species found along the Brazilian coast is the spotted scorpionfish Scorpaena plumieri. Though hardly ever life-threatening to humans, envenomation by S. plumieri can be quite hazardous, provoking extreme pain and imposing significant socioeconomic costs, as the victims may require days to weeks to recover from their injuries. In this review we will walk the reader through the biological features that distinguish this species as well as the current epidemiological knowledge related to the envenomation and its consequences. But above all, we will discuss the challenges involved in the biochemical characterization of the S. plumieri venom and its compounds, focusing then on the successful isolation and pharmacological... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Scorpionfish; Scorpaena plumieri venom; Inflammatory response; Proteolytic activity; Cardiovascular activity; Sp-GP; Plumieribetin; C-type lectins; Sp-CTx. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100205 |
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| Sakabe,Róberson; Moraes,Flávio Ruas de; Belo,Marco Antonio de Andrade; Pilarski,Fabiana; Moraes,Julieta Rodini Engrácia de. |
| The objective of this work was to investigate the effect of dietary supplementation with essential fatty acids on the kinetics of macrophage accumulation and giant cell formation in Nile tilapia (Oreochromis niloticus). The supplementation sources were soybean oil (SO, source of omega 6, n‑6) and linseed oil (LO, source of omega 3, n‑3), in the following proportions: 100% SO; 75% SO + 25% LO; 50% SO + 50% LO; 25% SO + 75% LO; and 100% LO (four replicates per treatment). After a feeding period of three months, growth performance was evaluated, and glass coverslips were implanted into the subcutaneous connective tissue of fish, being removed for examination at 2, 4, 6, and 8 days after implantation. Growth performance did not differ between treatments. Fish... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Oreochromis niloticus; Foreign body; Growth performance; Inflammatory response; Lipid nutrition. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-204X2013000300010 |
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| ABREU,DILAYLA K. DE; MONTEIRO,JANAINA M.; SOUZA,CAROLINA C.; KARAM,RAFAEL G.; FERNANDES,RENATA A.; LESSA,THAIS B.; FAGLIARI,JOSÉ J.; MIGLINO,MARIA ANGELICA; AMBROSIO,CARLOS EDUARDO. |
| Abstract Duchenne Muscular Dystrophy (DMD) is the most common X-linked muscular disease affecting humans. The Golden Retriever Muscular Dystrophy model (GRMD) is considerthe most suitable for several studies. This assay aims to quantify lymphocyte subpopulations CD4, CD5, and CD8, and standardize, the serum electrophoretic profile, to understand their contribution to the pathologic process in normal Golden Retriever dogs (GR group) and dystrophic´s (GRMD group), through the umbilical cord blood, in dogs aged from 2 to 3 months (GR II and GRMD II), and in dogs over 1 year of age (GR III and GRMD III). No significant differences were observed between the CD8+ lymphocyte subpopulations of the groups studied. The CD4+ and CD5+ lymphocyte subpopulations were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute phase protein; Dystrophic model; Immune behavior; Inflammatory response; Muscular dystrophy; Serum protein. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000602977 |
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| Li,Q.; Yu,Q.; Na,R.; Liu,B.. |
| We aimed to investigate the effect of etanercept, a tumor necrosis factor-α (TNF-α) inhibitor, on rat cardiomyocyte hypertrophy and its underlying mechanism. Primary neonatal rat cardiomyocytes were isolated from Sprague-Dawley rats. The model of rat cardiomyocyte hypertrophy was induced by endothelin, and then treated with different concentrations of etanercept (1, 10, and 50 μM). After treatment, cell counts, viability and cell apoptosis were evaluated. The mRNA levels of myocardial hypertrophy marker genes, including atrial natriuretic factor (ANF), matrix metalloproteinase (MMP)-9 and MMP-13, were detected by qRT-PCR, and the expressions of apoptosis-related proteins (Bcl-2 and Bax) were measured by western blotting. The protein levels of transforming... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tumor necrosis factor-α inhibitor; Endothelin; Myocardial hypertrophy; Cell apoptosis; Inflammatory response. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600604 |
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| Wang,Y.F.; Wu,M.; Ma,B.J.; Cai,D.A.; Yin,B.B.. |
| In this study, we investigated the potential role of high-mobility group box 1 (HMGB1) in severe acute pancreatitis (SAP) and the effects of growth hormone (G) and somatostatin (S) in SAP rats. The rats were randomly divided into 6 groups of 20 each: sham-operated, SAP, SAP+saline, SAP+G, SAP+S and SAP+G+S. Ileum and pancreas tissues of rats in each group were evaluated histologically. HMGB1 mRNA expression was measured by reverse transcription-PCR. Levels of circulating TNF-α, IL-1, IL-6, and endotoxin were also measured. In the SAP group, interstitial congestion and edema, inflammatory cell infiltration, and interstitial hemorrhage occurred in ileum and pancreas tissues. The levels of HMGB1, TNF-α, IL-1, IL-6 and endotoxin were significantly up-regulated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Severe acute pancreatitis; High-mobility group box 1; Growth hormone; Somatostatin; Inflammatory response. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201075 |
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| Sáez,J.C.; Brañes,M.C.; Corvalán,L.A.; Eugenín,E.A.; González,H.; Martínez,A.D.; Palisson,F.. |
| Gap junction channels are sites of cytoplasmic communication between contacting cells. In vertebrates, they consist of protein subunits denoted connexins (Cxs) which are encoded by a gene family. According to their Cx composition, gap junction channels show different gating and permeability properties that define which ions and small molecules permeate them. Differences in Cx primary sequences suggest that channels composed of different Cxs are regulated differentially by intracellular pathways under specific physiological conditions. Functional roles of gap junction channels could be defined by the relative importance of permeant substances, resulting in coordination of electrical and/or metabolic cellular responses. Cells of the native and specific... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cell contacts; Gap junctions; Connexins; Native immune response; Specific immune response; Inflammatory response. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400011 |
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| Salomão,R.; Ferreira,B.L.; Salomão,M.C.; Santos,S.S.; Azevedo,L.C.P.; Brunialti,M.K.C.. |
| Sepsis remains a major cause of morbidity and mortality worldwide, with increased burden in low- and middle-resource settings. The role of the inflammatory response in the pathogenesis of the syndrome has supported the modern concept of sepsis. Nevertheless, a definition of sepsis and the criteria for its recognition is a continuous process, which reflects the growing knowledge of its mechanisms and the success and failure of diagnostic and therapeutic interventions. Here we review the evolving concepts of sepsis, from the “systemic inflammatory response syndrome triggered by infection” (Sepsis-1) to “a severe, potentially fatal, organic dysfunction caused by an inadequate or dysregulated host response to infection” (Sepsis-3). We focused in the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sepsis-3; Inflammatory response; Immunometabolism; QSOFA; SOFA. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000400301 |
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| Wang,Wu-Ke; Tu,Chao-Yong; Shao,Chu-Xiao; Chen,Wei; Zhou,Qing-Yun; Zhu,Jing-De; Xu,Hong-Tao. |
| We determined the effects of enhanced recovery after surgery (ERAS) in patients undergoing radical surgery for gastric carcinoma. Sixty patients undergoing radical gastrectomy for gastric carcinoma in Lishui Hospital between March and October 2016 were randomized to receive either ERAS (30 patients) or conventional care (30 patients, controls). Clinical, economic, and laboratory indices were analyzed. ERAS patients showed faster recovery and shorter postoperative hospital stays than the controls (P<0.05). Some clinical indices (i.e., time to first flatus and defecation, time to removal of drainage tubes, time to resumption of oral feeding, time to postoperative mobilization, and postoperative complications) were significantly better in ERAS patients... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Enhanced recovery after surgery; Perioperative period; Gastric carcinoma; Inflammatory response; Immune function. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000500609 |
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| Registros recuperados: 12 | |
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