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Elastin (ELN) gene point mutation in patients with inguinal hernia Genet. Mol. Biol.
Rodrigues,Consuelo Junqueira; Yoo,Jin Hwan; Rodrigues Junior,Aldo Junqueira.
Groin hernias emerge at the myopectineal orifice of Fruchaud which is closed off by the fascia transversalis. Our previous studies showed structural and quantitative changes of the fascia transversalis elastic fibers of inguinal hernia patients and elderly people. The present study used single-strand conformation polymorphism (SSCP) elastin (analysis to investigate the 34 exons of the ELN gene of 49 inguinal hernia patients (7 females, 42 males aged 58.7 ± 19.82 years) and 75 non-herniated controls (35 females, 40 males aged 46.2 ± 14.32 years). We found that 47 patients and 24 controls had an abnormal exon 20 pattern caused by a g28197A > G missense mutation leading to an S422G amino acid substitution in the elastin hydrophobic domain. The g28197A >...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fascia transversalis; Extracellular matrix; Elastic fibers; Elastin gene; Inguinal hernia.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000100009
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Internal inguinal ring closure by laparoscopy using homologous pericardium grafts in horses Ciência Rural
Spagnolo,Julio David; Sinhorini,Idercio Luis; Baccarin,Raquel Yvonne Arantes; Ambrosio,Aline Magalhães; Souto,Maria Teresa de Mello; Ida,Keila Kazue; Silva,Luis Claudio Lopes Correia da.
ABSTRACT: The occlusion of inguinal ring is the treatment to avoid the inguinal hernia in horses. The aim of this study is evaluate the efficacy of homologous pericardium grafts for internal inguinal ring closure in horses, comparing mechanical or manual laparoscopic suture. Cross over study, using six healthy intact male Mangalarga breed horses aged between 3 and 12 years. Horses were operated under general anesthesia in 25º Trendelenburg position. Five laparoscopic portals were employed. Pericardium grafts measuring 4x5cm were anchored covering the left and right internal inguinal rings using either manual intracorporeal suture or laparoscopic stapler. Horses were followed-up during 11 weeks when were submitted to a laparoscopic control. Surgical time,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Equine; Inguinal hernia; Laparoscopy; Herniorraphy.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000200318
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