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| ARTHUR,WILLIAM T.; NOREN,NICOLE K.; BURRIDGE,KEITH. |
| Integrins and cadherins are transmembrane adhesion receptors that are necessary for cells to interact with the extracellular matrix or adjacent cells, respectively. Integrins and cadherins initiate signaling pathways that modulate the activity of Rho family GTPases. The Rho proteins Cdc42, Rac1, and RhoA regulate the actin cytoskeleton. Cdc42 and Rac1 are primarily involved in the formation of protrusive structures, while RhoA generates myosin-based contractility. Here we examine the differential regulation of RhoA, Cdc42, and Rac1 by integrin and cadherin signaling. Integrin and cadherin signaling leads to a decrease in RhoA activity and activation of Cdc42 and Rac1. When the normal RhoA suppression is antagonized or RhoA signaling is increased, cells... |
| Tipo: Journal article |
Palavras-chave: Integrins; Cadherins; Adhesion; Rho; Rac; Cdc42. |
| Ano: 2002 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200016 |
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| Savino,W.; Ayres Martins,S.; Neves-dos-Santos,S.; Smaniotto,S.; Ocampo,J.S.P.; Mendes-da-Cruz,D.A.; Terra-Granado,E.; Kusmenok,O.; Villa-Verde,D.M.S.. |
| Cell migration is a crucial event in the general process of thymocyte differentiation. The cellular interactions involved in the control of this migration are beginning to be defined. At least chemokines and extracellular matrix proteins appear to be part of the game. Cells of the thymic microenvironment produce these two groups of molecules, whereas developing thymocytes express the corresponding receptors. Moreover, although chemokines and extracellular matrix can drive thymocyte migration per se, a combined role for these molecules appears to contribute to the resulting migration patterns of thymocytes in their various stages of differentiation. The dynamics of chemokine and extracellular matrix production and degradation is not yet well understood.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Thymocyte migration; Extracellular matrix; Integrins; Chemokines; Thymic epithelial cells; Thymic nurse cells. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800007 |
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| Hynes,R.O.; Bader,B.L.; Hodivala-Dilke,K.. |
| Many growth factors and their protein kinase receptors play a role in regulating vascular development. In addition, cell adhesion molecules, such as integrins and their ligands in the extracellular matrix, play important roles in the adhesion, migration, proliferation, survival and differentiation of the cells that form the vasculature. Some integrins are known to be regulated by angiogenic growth factors and studies with inhibitors of integrin functions and using strains of mice lacking specific integrins clearly implicate some of these molecules in vasculogenesis and angiogenesis. However, the data are incomplete and sometimes discordant and it is unclear how angiogenic growth factors and integrin-mediated adhesive events cooperate in the diverse cell... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Vasculogenesis; Angiogenesis; Integrins; Knockout mice. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500002 |
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