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	Provedor de dados BJID (2) BJMBR (1) Autor Amaral,Ana Cristina (1) Conceição,Raquel D. O. (1) Curi,R. (1) Hirata,M.H. (1) Hirata,R.D.C. (1) Leite,Katia (1) Mangini,Cláudia (1) Nguyen,N.Y. (1) Oliveira,Ana Cláudia de (1) Parise,Edison Roberto (1) Pereira,Graziella Hanna (1) Russo,M. (1) Yoon,S. (1) Mais... Palavra-chave Interferon alpha (3) Autoimmune diseases (1) Chronic hepatitis C (1) Genotype 2 and 3 (1) Graft-versus-host disease (1) Haemophilia (1) Hepatic fibrosis (1) Inhibitor of interferon-a (1) Interferon-a receptor (1) Recombinant protein (1) Ribavirin (1) Ribavirin therapy (1) Treatment of chronic C hepatitis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2008 (1) 2006 (1) 2000 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Treatment of chronic hepatitis C virus infection among Brazilian haemophiliacs BJID Pereira,Graziella Hanna; Mangini,Cláudia. Chronic hepatitis C virus (HCV) infection is now the most important cause of liver cirrhosis and hepatocellular carcinoma worldwide. HCV infection prevalence is high among haemophiliacs (39%-98%), who got infected when received inadequately or non-virus-inactivated large-pool clotting factors concentrates before 1992. Current treatment reduces the probability of developing advanced stages of liver disease. The objective of this study was to evaluate efficacy and safety of the treatment with interferon alpha (IFN) and ribavirin in haemophiliacs. From July 2000 to November 2002, 18 patients were treated with IFN, three million units thrice weekly combined with daily oral doses of 1,000 or 1,250 mg of ribavirin for a minimum of 48 weeks. Eleven patients (61%)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic hepatitis C; Haemophilia; Interferon alpha; Ribavirin therapy. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100006 Response to treatment with interferon-alpha and ribavirin in patients with chronic Hepatitis C virus genotypes 2 and 3 depends on the degree of hepatic fibrosis BJID Parise,Edison Roberto; Oliveira,Ana Cláudia de; Conceição,Raquel D. O.; Amaral,Ana Cristina; Leite,Katia. The combined therapy with interferon alfa plus ribavirin (INF+RBV) is considered the most appropriate treatment for patients with chronic hepatitis C virus genotypes 2 and 3 in Brazil. However, wide variations in the rates of sustained viral response (SVR) have been reported among such patients. We evaluated, retrospectively, factors associated with SVR in subjects with chronic hepatitis C virus genotypes 2 and 3 and that received medication from the Health Secretariat of the state of São Paulo. One-hundred-seventy-seven consecutive patients with chronic hepatitis C were treated for 24 or 48 weeks according to the viral genotype. Patients co-infected with associated hepatic diseases or who had problems with alcohol abuse were excluded. The genotype of the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Interferon alpha; Ribavirin; Treatment of chronic C hepatitis; Genotype 2 and 3; Hepatic fibrosis. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200002 Expression and biological activity of two recombinant polypeptides related to subunit 1 of the interferon-a receptor BJMBR Yoon,S.; Hirata,R.D.C.; Nguyen,N.Y.; Curi,R.; Russo,M.; Hirata,M.H.. Abnormal production of interferon alpha (IFN-a) has been found in certain autoimmune diseases and can be also observed after prolonged therapy with IFN-a. IFN-a can contribute to the pathogenesis of allograft rejection in bone marrow transplants. Therefore, the development of IFN-a inhibitors as a soluble receptor protein may be valuable for the therapeutic control of these diseases. We have expressed two polypeptides encoding amino acids 93-260 (P1) and 261-410 (P2) of the extracellular domain of subunit 1 of the interferon-a receptor (IFNAR 1-EC) in E. coli. The activities of the recombinant polypeptides and of their respective antibodies were evaluated using antiproliferative and antiviral assays. Expression of P1 and P2 polypeptides was achieved by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Interferon alpha; Interferon-a receptor; Inhibitor of interferon-a; Autoimmune diseases; Graft-versus-host disease; Recombinant protein. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000700007 Registros recuperados: 3 Primeira ... 1 ... Última

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