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Heterogeneity of glomerular perfusion and filtration induced by epinephrine and norepinephrine BJMBR
Boim,M.A.; Stella,S.R.; Pereira,A.B.; Schor,N..
The role of catecholamines in the distribution of intrarenal blood flow and in single-nephron glomerular filtration rate (SNGFR) was evaluated in anesthetized Wistar rats by the Hanssen technique. Epinephrine (EPI) and norepinephrine (NOR) were infused to produce elevations of 20-30 mmHg in mean arterial pressure. Superficial and juxtamedullary nephron perfusion and filtration were determined by the presence of Prussian blue dye. In the control group, 100% of the nephrons presented a homogeneous pattern of perfusion and filtration. In contrast, a heterogeneous distribution of the dye was found even in the larger arteries (arciform and radial), indicating variable perfusion and filtration in both superficial and juxtamedullary nephrons. The effects of EPI...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Catecholamines; Intrarenal blood flow; Glomerular function; Hanssen technique; Micropuncture.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800017
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