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| Carvalho,Mário G. de; Silva,Virginia C. da; Silva,Tânia M.S. da; Camara,Celso A.; Braz-Filho,Raimundo. |
| The reaction of the flavonol 3,7,3', 4'-tetra-O-methylquercetin (1) and of the isoflavone 7,4'-di-O-methylgenistein (2) with alkaline iodine in methanol afforded four new iodine derivatives: 8-iodo-5-hydroxy-3,7,3', 4'-tetramethoxy- flavone (1a) and 6-iodo-5-hydroxy-3,7,3', 4'-tetramethoxyflavone (1b) from 1; 2 afforded a mixture of two compounds, identified as a racemic mixture of (±)-trans-5-hydroxy-2,3,7,4'-tetramethoxy-8-iodo-isoflavanone (2a) and (±)-trans-5-hydroxy-2,3,7,4'-tetramethoxy-6,8-diiodo-isoflavanone (2b). The formation of these different products reveals a significant difference involving the chemical interaction between the reactive site of α, β-unsaturated ketones of flavonol and isoflavone under the tested reaction conditions (using... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Flavonol; Isoflavone; Iodoflavonoid; Iodoisoflavonoid; Iodine derivatives. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000100004 |
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| PEREIRA,RAFAEL; PEREIRA,ANNA L.; FERREIRA,MARCILIO M.; FONTENELLE,RAQUEL O.S.; SAKER-SAMPAIO,SILVANA; SANTOS,HÉLCIO S.; BANDEIRA,PAULO N.; VASCONCELOS,MAYRON A.; QUEIROZ,JOSÉ A.N.; BRAZ-FILHO,RAIMUNDO; TEIXEIRA,EDSON H.. |
| Abstract: This study evaluated the antibacterial, antifungal, and antioxidant effect of 7-hydroxy-4’,6-dimethoxy-isoflavone and essential oil of Myroxylon peruiferum. The compound was isolated and its structure elucidated by NMR. The chemical composition of essential oil determined by GC-MS analysis. To evaluation of antimicrobial activity, the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration (MFC) were performed. In addition to analysis of antioxidant activity, DPPH radical scavenging tests, iron chelating assay (FIC), antioxidant reducing power assay (FRAP) and β-carotene bleaching assay (BCB) were performed. For the essential oil were identified 24 organized compounds having as main... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimicrobial activity; Antioxidant activity; Essential oil; Isoflavone; Myroxylon peruiferum. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300602 |
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| Santos-Galduróz,R.F.; Galduróz,J.C.F.; Facco,R.L.; Hachul,H.; Tufik,S.. |
| Hormone decline is common to all women during aging and, associated with other factors, leads to cognitive impairment. Its replacement enhances cognitive performance, but not all women present a clinical and family or personal history that justifies its use, mainly women with a history of cancer. The aim of this study was to determine whether a daily oral dose of 80 mg of isoflavone extract for 4 months can produce benefits in women with low hormone levels, contributing to improvement in cognitive aspects. The sample comprised 50- to 65-year-old women whose menstruation had ceased at least 1 year before and who had not undergone hormone replacement. The volunteers were allocated to two groups of 19 individuals each, i.e., isoflavone and placebo. There was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Isoflavone; Cognitive disorders; Aging; Information integration; Memory; Menopause. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100016 |
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| Neves,Michelline Viviane Marques das; Silva,Tânia Maria Sarmento da; Lima,Edeltrudes de Oliveira; Cunha,Emídio Vasconcelos Leitão da; Oliveira,Eduardo de Jesus. |
| Abstract A bioassay-guided fractionation of two samples of Brazilian red propolis (from Igarassu, PE, Brazil, hereinafter propolis 1 and 2) was conducted in order to determine the components responsible for its antimicrobial activity, especially against Candida spp. Samples of both the crude powdered resin and the crude ethanolic extract of propolis from both locations inhibited the growth of all 12 tested Candida strains, with a minimum inhibitory concentration of 256 µg/mL. The hexane, acetate and methanol fractions of propolis 1 also inhibited all strains with minimum inhibitory concentration values ranging from 128 to 512 µg/mL for the six bacteria tested and from 32 to 1024 µg/mL for the yeasts. Similarly, hexane and acetate fractions of propolis... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bioassay-guided fractionation; Red propolis; Isoflavone; Formononetin; Candida. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000100159 |
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