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| Genta,P.R.; Marcondes,B.F.; Danzi,N.J.; Lorenzi-Filho,G.. |
| Some studies showed that Asians with obstructive sleep apnea (OSA) are thinner than Caucasians. Because obesity is a major risk factor for OSA, it was concluded that Asians are predisposed to OSA. However, body fat composition varies for a same body mass index (BMI) according to ethnicity. We firstly compared anthropometric characteristics, symptoms and associated disorders in all consecutive male Japanese descendants and white males with OSA referred for polysomnography. In a second analysis, all Japanese descendants were compared to a subgroup of white males, matched for apnea/hypopnea index and age. In the first analysis, age, symptoms, OSA severity and co-morbidities were similar among Japanese descendants (N = 54) and white patients (N = 466).... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Asians; Obesity; Obstructive sleep apnea; Japanese; Ethnicity; Body mass index. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000800015 |
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| Perini,J.A.; Vargens,D.D.; Santana,I.S.C.; Moriguchi,E.H.; Ribeiro-dos-Santos,A.K.C.; Tsutsumi,M.; Suarez-Kurtz,G.. |
| Brazil hosts the largest Japanese community outside Japan, estimated at 1.5 million individuals, one third of whom are first-generation, Brazilian-born with native Japanese parents. This large community provides a unique opportunity for comparative studies of the distribution of pharmacogenetic polymorphisms in native Japanese versus their Brazilian-born descendants. Functional polymorphisms in genes that modulate drug disposition (CYP2C9, CYP2C19 and GSTM3) or response (VKORC1) and that differ significantly in frequency in native Japanese versus Brazilians with no Japanese ancestry were selected for the present study. Healthy subjects (200 native Japanese and 126 first-generation Japanese descendants) living in agricultural colonies were enrolled.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Japanese; Brazil; CYP2C9; CYP2C19; GSTM3; VKORC1. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200010 |
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