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	Provedor de dados BJMBR (1) BJPS (1) Autor Furth,S.L. (1) Jiang,Guohong (1) Kovesdy,C.P. (1) Ma,Peilong (1) Song,Rixin (1) Zoccali,C. (1) Mais... Palavra-chave Kidney cancer (2) CD40L (1) Chronic kidney disease (1) DNA vaccine (1) G250 (1) Nephrolithiasis (1) Obesity (1) Prevention (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2019 (1) 2017 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Obesity and kidney disease: hidden consequences of the epidemic BJMBR Kovesdy,C.P.; Furth,S.L.; Zoccali,C.. Obesity has become a worldwide epidemic and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for chronic kidney disease (CKD). A high body mass index is one of the strongest risk factors for new-onset CKD. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing CKD in the long-term. The incidence of obesity-related glomerulopathy has increased ten-fold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis, and for a number... Tipo: Info:eu-repo/semantics/other Palavras-chave: Obesity; Chronic kidney disease; Nephrolithiasis; Kidney cancer; Prevention. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000500101 Enhancing immune effects of a DNA vaccine against kidney cancer using CD40L as an adjuvant BJPS Jiang,Guohong; Song,Rixin; Ma,Peilong. The use of specific combinations of antigens and adjuvant represents a promising approach for increasing the immunogenicity of DNA vaccines. In the present study, we evaluated the immunity and antitumor effects of DNA vaccines with G250 as the target antigen in a mouse model of renal cell carcinoma. We constructed two recombinant plasmids, pVAX1-G250 and pVAX1-CD40L. The recombinant plasmids were injected into mice by intramuscular injection and electrical pulse stimulation. ELISA and ELISPOT experiments were performed to evaluate the corresponding humoral and cellular immune responses following immunization. To further investigate the antitumor potential of the DNA vaccines, we established a tumor-bearing mouse model expressing G250 target antigen. Our... Tipo: Info:eu-repo/semantics/article Palavras-chave: Kidney cancer; G250; CD40L; DNA vaccine. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100555 Registros recuperados: 2 Primeira ... 1 ... Última

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