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Glutamatergic neurotransmission modulates hypoxia-induced hyperventilation but not anapyrexia BJMBR
Paula,P.M. de; Branco,L.G.S..
The interaction between pulmonary ventilation (V E) and body temperature (Tb) is essential for O2 delivery to match metabolic rate under varying states of metabolic demand. Hypoxia causes hyperventilation and anapyrexia (a regulated drop in Tb), but the neurotransmitters responsible for this interaction are not well known. Since L-glutamate is released centrally in response to peripheral chemoreceptor stimulation and glutamatergic receptors are spread in the central nervous system we tested the hypothesis that central L-glutamate mediates the ventilatory and thermal responses to hypoxia. We measured V E and Tb in 40 adult male Wistar rats (270 to 300 g) before and after intracerebroventricular injection of kynurenic acid (KYN, an ionotropic glutamatergic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Kynurenic acid -->; Alpha-Methyl-4-carboxyphenyl-glycine (MCPG) Hypoxia Ventilation Body temperature.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001000019
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