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Malnutrition affects the pressor response to microinjection of L-glutamate into the RVLM of awake rats Biol. Res.
Rodrigues,Fabiana Aparecida; Chianca-Jr,Deoclecio Alves; Gonçalves Fernandes,Luciano.
Post-weaning protein malnutrition is often related to the development of cardiovascular and metabolic diseases in humans, as well to changed content of neurotransmitters in the central nervous system under experimental conditions. The rostral ventrolateral medulla (RVLM) is a bulbar region that contains sympathetic premotor neurons; the excitatory amino acid L-glutamate seems to be the main neurotransmitter at this level. The aim of the present study was to evaluate the possible change in the L-glutamate sensitivity of the RVLM neurons of malnourished animals. Male Fischer rats were divided into two groups: control (n = 15) and malnourished (n = 19). Four days before the experiments, guide cannulas were implanted bilaterally in direction of the RVLM for...
Tipo: Journal article Palavras-chave: Baroreflex; Blood pressure; L-glutamate receptors; Heart rate; Malnutrition; RVLM.
Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000400002
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