Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados 60 (2) Autor Alexandre,Veriano (1) Baldoni,André Oliveira (1) Ferreira,Flávia Isaura de Santi (1) Freitas-Lima,Priscila (1) Martinez,Edson Zangiacomi (1) Martins,Magda Targa (1) Paim,Clésio Soldatelli (1) Pereira,Leonardo Regis Leira (1) Queiroz,Regina Helena Costa (1) Sakamoto,Americo Ceiki (1) Steppe,Martin (1) Mais... Palavra-chave Lamotrigine (2) Dissolution test/validation (1) Drug interaction (1) Medicines/quality control (1) Refractory Epilepsy (1) Therapeutic drug monitoring. (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2010 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Development of a dissolution test for lamotrigine in tablet form using an ultraviolet method 60 Martins,Magda Targa; Paim,Clésio Soldatelli; Steppe,Martin. A dissolution test for tablets containing 100 mg of lamotrigine was developed and validated. The dissolution test was applied to compare the dissolution profile of Neural® with the reference product Lamictal®. The analysis procedure was carried out using a simple ultraviolet method at 267 nm. After the determination of solubility and sink conditions, the parameters selected were paddles at 50 rpm, 900 mL of 0.01 M hydrochloric acid, and 30 minutes duration (single point). This method was validated for specificity, linearity, accuracy, precision and robustness. Lamotrigine stability was also evaluated in dissolution medium. Tipo: Info:eu-repo/semantics/article Palavras-chave: Lamotrigine; Dissolution test/validation; Medicines/quality control. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200003 Influence of the clinical profile of patients with refractory epilepsy on lamotrigine plasma concentration 60 Baldoni,André Oliveira; Freitas-Lima,Priscila; Alexandre,Veriano; Ferreira,Flávia Isaura de Santi; Martinez,Edson Zangiacomi; Queiroz,Regina Helena Costa; Sakamoto,Americo Ceiki; Pereira,Leonardo Regis Leira. ABSTRACT The purpose of this work was to evaluate the influence of the clinical profile on lamotrigine (LTG) plasma concentrations from patients with refractory epileptic seizures. In this cross-sectional study, therapeutic monitoring of LTG, and questionnaires with 75 patients with refractory epileptic seizures of a Hospital in Ribeirão Preto-SP-Brazil were performed. The multiple linear regression model was used to verify association between the LTG plasma concentrations and the independent variables. Covariance analysis was used to compare the mean LTG plasma concentration among the co-medication groups. The LTG plasma concentration was associated both with the LTG dosage (mg/kg/day) (p=0.0096) and with the use of first generation antiepileptic drugs... Tipo: Info:eu-repo/semantics/article Palavras-chave: Lamotrigine; Refractory Epilepsy; Drug interaction; Therapeutic drug monitoring.. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200624 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco