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	Provedor de dados BJMBR (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Braz,Lucia Maria Almeida (1) Lindoso,Jose Angelo Lauletta (1) Mendonça,Daiane Barros Dias (1) Palace-Berl,Fanny (1) Silva,Renata Ellen Costa (1) Soares,Sandra Regina C (1) Takakura,Cleusa FH (1) Tavares,Leoberto Costa (1) Mais... Palavra-chave Leishmania (L.) amazonensis (2) Carbohydrate antigens (1) Fast atom bombardment mass spectrometry (1) Glycosphingolipids (1) Leishmaniasis treatment (1) Monoclonal antibodies (1) Nitro-heterocyclic compounds (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2019 (1) 1997 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Nitro-Heterocyclic compounds induce apoptosis-like effects in Leishmania (L). amazonensis promastigotes J. Venom. Anim. Toxins incl. Trop. Dis. Mendonça,Daiane Barros Dias; Silva,Renata Ellen Costa; Palace-Berl,Fanny; Takakura,Cleusa FH; Soares,Sandra Regina C; Braz,Lucia Maria Almeida; Tavares,Leoberto Costa; Lindoso,Jose Angelo Lauletta. Abstract Background: Three drugs - pentavalent antimonials, amphotericin B and pentamidine - are currently used for leishmaniasis treatment. They are administered for long periods, only parenterally, and have high cardiac, renal and hepatic toxicities. Therefore, the investigation of new compounds is required. Nitro-heterocyclic derivatives have been used as possible drug candidates to treat diseases caused by trypanosomatids. Methods: Leishmania (L.) amazonensis promastigotes (MHO/BR/73/M2269), maintained in the Laboratório de Soroepidemiologia - Instituto de Medicina Tropical- USP, were exposed to five nitroheterocyclic derivatives, with differences at phenyl-ring position 4: BSF-C4H9, BSF-H, BSF-NO2, BSF-CH3 and BSF-Cl, for 48 hours. After analyzing... Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmaniasis treatment; Nitro-heterocyclic compounds; Leishmania (L.) amazonensis. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100303 Glycosphingolipid antigens from Leishmania (L.) amazonensis amastigotes: Binding of anti-glycosphingolipid monoclonal antibodies in vitro and in vivo BJMBR Specific glycosphingolipid antigens of Leishmania (L.) amazonensis amastigotes reactive with the monoclonal antibodies (MoAbs) ST-3, ST-4 and ST-5 were isolated, and their structure was partially elucidated by negative ion fast atom bombardment mass spectrometry. The glycan moieties of five antigens presented linear sequences of hexoses and N-acetylhexosamines ranging from four to six sugar residues, and the ceramide moieties were found to be composed by a sphingosine d18:1 and fatty acids 24:1 or 16:0. Affinities of the three monoclonal antibodies to amastigote glycosphingolipid antigens were also analyzed by ELISA. MoAb ST-3 reacted equally well with all glycosphingolipid antigens tested, whereas ST-4 and ST-5 presented higher affinities to... Palavras-chave: Glycosphingolipids; Monoclonal antibodies; Leishmania (L.) amazonensis; Fast atom bombardment mass spectrometry; Carbohydrate antigens. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000300014 Registros recuperados: 2 Primeira ... 1 ... Última

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