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| Registros recuperados: 68 | |
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| Ramayo,L.G.; Estevez,J.O.; Nevot,M.C.; Stempler,A; Goldman,L.; Jar,A.M.; Mundo,S.L.. |
| La leishmaniasis visceral es una enfermedad zoonótica producida por el protozoario Leishmania infantum (syn. chagasi) transmitida por el flebótomo Lutzomyia longipalpis y que tiene al canino como principal reservorio en áreas urbanas y periurbanas. En el presente trabajo se realizó un estudio electroforético retrospectivo de 40 sueros de caninos enfermos con diagnóstico parasitológico confirmado de leishmaniasis obtenidos entre los años 2006 y 2008 en la ciudad de Posadas, provincia de Misiones, Argentina. El 80 % (32 de 40) de las muestras presentaron alteraciones en el perfil electroforético caracterizadas por la disminución de la relación albúmina/globulina y la presencia de hipergammaglobulinemia de tipo policlonal en el 52,5 % de los casos (21 de 40)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Canino; Electroforesis; Leishmaniasis; Hipergammaglobulinemia. |
| Ano: 2011 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1668-34982011000200008 |
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| Braga,Audrey Rennó Campos; Langoni,Hélio; Lucheis,Simone Baldini. |
| Background: This study aimed to evaluate the occurrence of Leishmaniaspp. in dogs and cats from Botucatu, São Paulo state, and Campo Grande, Mato Grosso do Sul state, Brazil, by the association of three diagnostic tests: blood culture in liver infusion tryptose medium, immunofluorescent antibody test and polymerase chain reaction. Fifty blood samples of dogs and cats from the Center for Zoonosis Control in Campo Grande, an area endemic for canine visceral leishmaniasis, were collected randomly, as well as canine and feline blood samples from the Municipal Kennel and Animal Protection Association in Botucatu, currently considered a transmission-free, non-endemic area.Results: Of the 50 dog blood cultures from Botucatu, three (6%) were positive and of the 50... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dog; Cat; Diagnosis; Leishmaniasis; Zoonosis. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200323 |
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| Gonçalves-de-Albuquerque,Suênia da Cunha; Silva,Rômulo Pessoa e; Morais,Rayana Carla Silva de; Trajano-Silva,Lays Adrianne Mendonça; Régis-da-Silva,Carlos Gustavo; Brandão Filho,Sinval Pinto; Paiva-Cavalcanti,Milena de. |
| Background : Molecular biological methods have become increasingly relevant to the diagnosis and control of infectious diseases, such as leishmaniasis. Since various factors may affect the sensitivity of PCR assays, including DNA yield and purity, an optimal extraction method is pivotal. Losses of a parasite’s DNA during extraction may significantly impair its detection by PCR and lead to false-negative results. This study proposes a triplex PCR assay targeting the parasite’s DNA, an external control (pUC18) and an internal control (G3PD) for accurate diagnosis of leishmaniasis.Results : Two primer pairs were designed to detect the plasmid pUC18 and a triplex PCR assay targeting theLeishmania braziliensiskinetoplast DNA, the external control and the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Extraction control; Multiplex PCR; PUC18; Leishmaniasis; Diagnosis; False-negative result. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200326 |
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| Camargo,L. B; Langoni,H.. |
| Leishmaniasis is a parasitic zoonosis caused by protozoans of the genus Leishmania transmitted by insects known as phlebotomines, which are found in wild or urban environments. It affects domestic and wild animals and transmission to man happens by accident. The disease occurs in tropical and sub-tropical areas, mainly in Asia, Europe, Africa, and the Americas. There are two forms that affect man: American cutaneous leishmaniasis (ACL) and American visceral leishmaniasis (AVL). The latter is caused by three species of Leishmania: Leishmania (Leishmania) donovani, Leishmania (Leishmania) infantum, and Leishmania (Leishmania) chagasi, which are grouped in the Leishmania (Leishmania) donovani complex. Wild reservoir hosts of L. chagasi known so far are foxes... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leishmaniasis; Cutaneous leishmaniasis; Visceral leishmaniasis; Leishmania. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000400002 |
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| Volpedo,Greta; Costa,Lourena; Ryan,Nathan; Halsey,Gregory; Satoskar,Abhay; Oghumu,Steve. |
| Abstract Neglected Tropical Diseases (NTDs) comprise of a group of seventeen infectious conditions endemic in many developing countries. Among these diseases are three of protozoan origin, namely leishmaniasis, Chagas disease, and African trypanosomiasis, caused by the parasites Leishmania spp., Trypanosoma cruzi, and Trypanosoma brucei respectively. These diseases have their own unique challenges which are associated with the development of effective prevention and treatment methods. Collectively, these parasitic diseases cause more deaths worldwide than all other NTDs combined. Moreover, many current therapies for these diseases are limited in their efficacy, possessing harmful or potentially fatal side effects at therapeutic doses. It is therefore... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leishmaniasis; Chagas; Trypanosomiasis; Nanoparticles; Liposomes; Nanotubes; Nanodiscs; Micelles. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100201 |
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| Faiões,Viviane dos Santos; Frota,Lívia C. R. M. da; Cunha-Junior,Edézio Ferreira; Barcellos,Julio C. F.; Silva,Thayssa Da; Daher Netto,Chaquip; Da-Silva,Silvia Amaral Gonçalves; Silva,Alcides J. M. da; Costa,Paulo R. R.; Torres-Santos,Eduardo Caio. |
| Abstract Background: Despite the development of new therapies for leishmaniasis, among the 200 countries or territories reporting to the WHO, 87 were identified as endemic for Tegumentary Leishmaniasis and 75 as endemic for Visceral Leishmaniasis. The identification of antileishmanial drug candidates is essential to fill the drug discovery pipeline for leishmaniasis. In the hit molecule LQB-118 selected, the first generation of pterocarpanquinones was effective and safe against experimental visceral and cutaneous leishmaniasis via oral delivery. In this paper, we report the synthesis and antileishmanial activity of the second generation of pterocarpanoquinones. Methods: The second generation of pterocarpanquinones 2a-f was prepared through a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leishmania; Pterocarpanquinone; LQ-118; Phenotypic assay; Leishmaniasis; Drug discovery; Neglected diseases. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100325 |
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| Pereira,Andreia Vieira; Barros,Gustavo de; Pinto,Erika Gracielle; Tempone,Andre Gustavo; Orsi,Ricardo de Oliveira; Santos,Lucilene Delazari dos; Calvi,Sueli; Ferreira Jr,Rui Seabra; Pimenta,Daniel Carvalho; Barraviera,Benedito. |
| Abstract Background Apis mellifera venom, which has already been recommended as an alternative anti-inflammatory treatment, may be also considered an important source of candidate molecules for biotechnological and biomedical uses, such as the treatment of parasitic diseases. Methods Africanized honeybee venom from Apis mellifera was fractionated by RP-C18-HPLC and the obtained melittin was incubated with promastigotes and intracellular amastigotes of Leishmania (L.) infantum. Cytotoxicity to mice peritoneal macrophages was evaluated through mitochondrial oxidative activity. The production of anti- and pro-inflammatory cytokines, NO and H2O2 by macrophages was determined. Results Promastigotes and intracellular amastigotes were susceptible to melittin... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Melittin; Apis mellifera; Leishmania; Leishmaniasis; Peptides; Toxins; Antiparasitic; Cytokines. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100301 |
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| Rosa,Juan R; Salomon,Oscar D; Andrade Filho,José D; Carvalho,Gustavo M L; Szelag,Enrique A; Stein,Marina; Tapia,Eliana S; Brazil,Reginaldo P. |
| The phlebotomine sandflies of the province of Chaco, Argentina, are poorly known, with reports from more than 40 years or captures related with outbreaks of leishmaniasis. In here, Mycropygomyia peresi (Mangabeira) is reported for the first time in Argentina, extending the known dstribution of Migonemyia migonei (França), Evandromyia sallesi (Galvão & Coutinho), Mycropygomyia quinquefer (Dyar), Brumptomyia brumpti (Larousse) y Nemapalpus spp to the province of Chaco. Mg. migonei, together with Nyssomyia neivai (Pinto), Evandromyia cortelezzii (Brèthes), and Psathyromyia shannoni (Dyar) also captured in Chaco, were incriminated as vectors of Leishmania in Argentina. |
| Tipo: Info:eu-repo/semantics/report |
Palavras-chave: Leishmaniasis; Migonemyia migonei; Evandromyia sallesi; Mycropygomyia quinquefer; Mycropygomyia peresi. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2010000200024 |
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| Souza,Cristian F; Borges,Magno A Z; Andrade,Andrey J. |
| An investigation of the phlebotomine sandfloy fauna in the municipality of Timóteo, Minas Gerais State, Brazil, was undertaken with New Jersey traps placed in seven neighborhoods from December 2005 to January 2006. A total of 2,289 phlebotomine sandfloy specimens were recorded. Nyssomyia whitmani (Antunes & Coutinho) (48.1%), Nyssomyia intermedia (Lutz & Neiva) (36.8%) and Micropygomyia quinquefer (Dyar) (7.1%) were the most abundant species sampled. Some sandfloy species that play a role in the transmission of Leishmania Ross in the State of Minas Gerais were recorded and their importance to public health is highlighted. Pintomyia bianchigalatiae (Andrade Filho, Aguiar, Dias & Falcão), Micropygomyia capixaba (Dias, Falcão, Silva... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sandfloy; Leishmaniasis; Phlebotominae; Pressatia choti; Public health. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2009000200016 |
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| Silva,Francinaldo S; Carvalho,Luis P C de; Cardozo,Francisco P; Moraes,Jorge L P; Rebêlo,José M M. |
| The present paper aims to increase the knowledge on the sand fly fauna in the cerrado areas of Maranhão state in urban, rural and forest environments. The research was carried out from October 2007 to September 2008, between 18:00h and 06:00h, in the municipality of Chapadinha, northeast Maranhão. For insect sampling, CDC light traps were set up in peridomicile and domicile areas of urban and rural zones as well as in Cerrado and Gallery forests. The total of 1,401 specimens belonging to 17 species were sampled, all within the genus Lutzomyia. Lutzomyia longipalpis (Lutz & Neiva) (52.5%), Lu. evandroi (Costa Lima & Antunes) (18.3%), Lu. whitmani (Antunes & Coutinho) (12.1%), Lu. lenti (Mangabeira) (4.7%) and Lu. termitophila... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leishmaniasis; Lutzomyia; Insect vector. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2010000600028 |
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| Andrade Filho,José D; Brazil,Reginaldo P. |
| The phlebotomine sandflies of the state of Alagoas are poorly known, with more than 40 years since the last report on sandflies in the state. In here, Psathyromyia brasiliensis (Costa Lima), Micropygomyia quinquefer (Dyar,) and Evandromyia termitophila (Martins, Falcão & Silva) are registered for the first time in Alagoas. This report increases to nine the number of species collected in the state, including Lutzomyia longipalpis (Lutz & Neiva), Migonemyia migonei (França), Nyssomyia whitmani (Antunes & Coutinho) and Nyssomyia intermedia (Lutz & Neiva), all vectors of Leishmania in Brazil. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leishmaniasis; Migonemyia migonei; Psathyromyia brasiliensis; Micropygomyia quinquefer; Evandromyia termitophila. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2009000500022 |
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| Silva,MH; Nascimento,MDSB; Leonardo,FS; Rebêlo,JMM; Pereira,SRF. |
| Entomological surveys in the state of Maranhão have recorded morphologically distinct populations of Lutzomyia longipalpis (Lutz & Neiva). Some populations have one pair of spots (1S) on the fourth tergite, while others have two pairs (2S) on the third and fourth tergites of males. In the present study we investigated the degree of genetic polymorphism among four populations in the municipalities of Caxias, Codó and Raposa, in the state of Maranhão, Brazil, by using RAPD (Random Amplified Polymorphic DNA) markers. A total of 35 loci were identified, of which 30 were polymorphic. The highest polymorphism was observed with primer OPA 4, which produced 11 different profiles. Genetic diversity was assessed using grouping methods that produced a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Abdominal spot; Genetic polymorphism; Leishmaniasis; RAPD-PCR; Sand fly. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2011000400015 |
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| Galati,Eunice A. B.; Marassá,Ana Maria; Gonçalves-Andrade,Rute Maria; Consales,Cleide Aschenbrenner; Bueno,Edna Fátima Maria. |
| The Parque Estadual do Alto Ribeira (PETAR) with about 250 caves, in an Atlantic forest reserve, is an important ecotourist attraction in the Ribeira Valley, an endemic area of American cutaneous leishmaniasis (ACL). With the purpose of investigating Leishmania vector species bothersome to humans the sandfly fauna was identified and some of its ecological aspects in the Santana nucleus, captures were undertaken monthly with automatic light traps in 11 ecotopes, including caves, forests, a camping site and domiciliary environments, and on black and white Shannon traps, from January/2001 to December/2002. A total of 2,449 sandflies representing 21 species were captured. The highest values of abundance obtained in the captures with automatic light traps were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Caves; Ecology; Leishmaniasis; Sandfly; Vectors. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0085-56262010000300020 |
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| Galati,Eunice Aparecida Bianchi; Marassá,Ana Maria; Gonçalves-Andrade,Rute Maria; Consales,Cleide Aschenbrenner; Bueno,Edna F. M.. |
| The identification of the sandfly fauna and investigation of some ecological aspects of its populations in areas frequented by tourists of the PEI, an Atlantic forest reserve with many caves, were the objective of this study. Captures were undertaken monthly from January 2001 to December 2002, with automatic light traps installed in 13 ecotopes, including caves, forests, domiciliary and peridomiciliary environments, and by aspiration in armadillo burrows. Additionally, although not at regular intervals, Shannon traps were installed in forests and anthropic environments, aspirations were made on cave walls, among roots and fallen leaves, and some insects were captured while biting researchers. A total of 891 sandflies belonging to 21 species were captured.... |
| Tipo: Info:eu-repo/semantics/report |
Palavras-chave: Atlantic forest; Cave; Leishmaniasis; Vectors. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0085-56262010000200015 |
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| Cardona Galeano,Wilson; Robledo Restrepo,Sara M; Rojano,Benjamín Alberto; Alzate Guarin,Fernando; Muñoz Herrera,Diana Lorena; Saez Vega,Jairo. |
| Introducción: la leishmaniasis es la enfermedad protozoaria responsable de la mayor morbilidad y mortalidad en la población mundial. Los medicamentos utilizados para su tratamiento presentan serios problemas, entre estos la alta toxicidad y los efectos secundarios severos. Por otro lado, la producción de radicales libres debido al estrés oxidativo ocasiona la oxidación de lípidos, proteínas, DNA y enzimas que son responsables del daño del tejido celular. Algunas especies de la familia Piperaceae presentan un amplio espectro de actividades biológicas, lo cual incita a la exploración de la propiedad antioxidante y antiprotozoaria en miembros del género Piper, como una alternativa en la búsqueda de nuevos medicamentos contra la leishmaniasis y de nuevos... |
| Tipo: Journal article |
Palavras-chave: Piper daniel-gonzalezii; Leishmaniasis; Antioxidantes. |
| Ano: 2013 |
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962013000200010 |
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| Espitia-Baena,Jorge Eliecer; Robledo-Restrepo,Sara María; Soraya Cuadrado-Cano,Bernarda; Duran-Sandoval,Harriette del Rosario; Gómez-Estrada,Harold Alberto. |
| Introducción: la leishmaniasis constituye un grave problema de salud pública a nivel mundial. En Colombia, la forma clínica cutánea tiene la mayor incidencia y es causada principalmente por especies de Leishmania (Viannia) panamensis. Dado que los tratamientos disponibles para esta enfermedad resultan ineficaces, es necesaria la búsqueda de nuevos agentes terapéuticos en especies vegetales utilizadas por la medicina popular. Objetivo: evaluar el perfil fitoquímico, la actividad hemolítica, citotóxica y anti-Leishmania in vitro de extractos y fracciones provenientes de hojas de Cordia dentata y Heliotropium indicum. Métodos: al extracto etanólico total y fracciones obtenidas de hojas de C. dentata y H. indicum, se les realizó perfil fitoquímico,... |
| Tipo: Journal article |
Palavras-chave: Leishmaniasis; Citotoxicidad; Cordia dentata; Heliotropium indicum. |
| Ano: 2014 |
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962014000300009 |
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| Feitosa,Marlisson Augusto Costa; Julião,Genimar Rebouças; Costa,Manoel Djalma Pereira; Belém,Braulio; Pessoa,Felipe Arley Costa. |
| This paper aimed to evaluate the richness, abundance and frequency of sand fly occurrence in rural and urban areas American visceral Leishmaniasis -AVL is endemic in the study area of Santarém municipality, Pará state. Sand flies were collected during 1995-2000, using CDC light traps placed in neighborhoods and rural areas of the municipality. A total of 53.454 individuals and 26 species of sand flies were collected. The most abundant species in both urban and rural environments was Lutzomyia longipalpis, vector of AVL in the area. The highest species richness by capture was in rural area. In all years sampled, the largest number of species of sand fly collected was always in rural areas. The species of sand flies in urban and rural area were similar in 11... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leishmaniasis; Anthropic impact; Amazon. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672012000400008 |
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| Registros recuperados: 68 | |
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