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| LIPPS,B. V.. |
| Currently, the use of antivenoms is the only available treatment for envenomation caused by venomous animals namely, snake, scorpion, spider, tick and jelly fish. Antivenoms are generally produced in large animals, mostly in horses. A large percentage of the population is allergic to horse proteins. Several animals are known to be resistant to snakebites and the antihemorrhagic and anti-lethal components have been isolated from sera of opossum, mongoose, meerkat and hedgehog, as well as from venomous and non-venomous snakes. Anti-lethal factor named Lethal Toxin Neutralizing Factor (LTNF) has been isolated in purity from opossum (Didelphis virginiana) serum by high pressure liquid chromatography (HPLC). The molecular weight of LTNF is 63 kDa, and it does... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Opossum; Didelphis virginiana; Lethal toxin neutralizing factor. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301999000100005 |
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| LIPPS,B. V.. |
| Lethal Toxin Neutralizing Factor (N-LTNF), MW 63.0 kDa, was isolated from opossum serum. After trypsin digestion, the active domain of N-LTNF was isolated and sequenced. The synthetic peptide consisting of ten amino acids was designated as LT-10. N-LTNF and LT-10 inhibited the lethality of animal, plant and bacteria toxins when tested on mice non-immunologically. The antibodies against N-LTNF and LT-10 only reacted immunologically with toxins and not with non-toxic substances. Anti-LTNF and anti-LT-10 reacted immunologically by ELISA test with toxins that were not detected by mouse test, such as cholera toxin and digoxin. Anti-LTNF and anti-LT-10 failed to react immunologically with non-toxic substances, such as nerve growth factor and collagen. Currently,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antibodies; In vitro assay; Lethal toxin neutralizing factor; Toxins; Venoms. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302002000200003 |
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