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	Provedor de dados J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Gabriel,LM (1) Sanchez,EF (1) Santos,RG (1) Silva,SG (1) Palavra-chave ECD-disintegrin (1) In vitro study (1) Leucurolysin-B (1) Snake venom (1) Tumor (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2012 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Tumor cytotoxicity of leucurolysin-B, a P-III snake venom metalloproteinase from Bothrops leucurus J. Venom. Anim. Toxins incl. Trop. Dis. Gabriel,LM; Sanchez,EF; Silva,SG; Santos,RG. Although it has been demonstrated that venoms and toxins from some snakes are able to influence the growth of tumor cells, few antitumoral compounds from Bothrops leucurus venom have been characterized. Leucurolysin-B (leuc-B) is a metalloproteinase class P-III isolated from B. leucurus which possesses an ECD-disintegrin domain. Both ECD-disentegrin and RGD-disintegrin are able to bind to cell surface integrins and inhibit their adherence to their natural ligands. In the present study, the potential efficacy and the cytotoxic effects of leuc-B on glioblastoma, breast cancer and melanoma cell lines were analyzed. The effect of leuc-B on cancer cell survival was evaluated and its 50% inhibitory concentration (IC50) was determined. Morphological alterations... Tipo: Info:eu-repo/semantics/article Palavras-chave: Snake venom; Leucurolysin-B; ECD-disintegrin; Tumor; In vitro study. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100004 Registros recuperados: 1 Primeira ... 1 ... Última

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