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	Provedor de dados BJPS (2) Autor Awen,Bahlul Zayed Shtaiwy (1) Boralli,Vanessa Bergamin (1) Challa,Balasekhara Reddy (1) Chandu,Babu Rao (1) Rezende,Gustavo Rodrigues de (1) Shaik,Rihana Parveen (1) Silva,Suéllen Cristina Rennó (1) Mais... Palavra-chave Liquid chromatography/quantitative analysis (2) Human plasma/determination of simvastatin (1) Mass spectrometry/quantitative analysis (1) Naratriptan/determination (1) Naratriptan/human plasma (1) Simvastatin/bioequivalence (1) Simvastatin/determination (1) Simvastatin/pharmacokinetics (1) Tandem mass spectrometry/quantitative analysis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2014 (1) 2011 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Quick and simple LC-MS/MS method for the determination of simvastatin in human plasma: application to pharmacokinetics and bioequivalence studies BJPS Silva,Suéllen Cristina Rennó; Rezende,Gustavo Rodrigues de; Boralli,Vanessa Bergamin. A simple, rapid, and sensitive method based on liquid chromatography-tandem mass spectrometry for the quantitative determination of simvastatin in human plasma was developed and validated. After a simple extraction with methyl tert-butyl ether, the analyte and internal standard (lovastatin) were analyzed using reverse-phase liquid chromatography, on a Kinetex C18column (100 × 4.6 mm, 2.6 μm) using acetonitrile: ammonium acetate (2 mM + 0.025 % formic acid) (70: 30, v/v) as a mobile phase in a run time of 3.5 min. Detection was carried out using electrospray positive ionization mass spectrometry in the multiple-reaction monitoring mode. The method was linear over 0.04-40.0 ng/mL concentration range. The mean extraction recovery of simvastatin was 82% (RSD... Tipo: Info:eu-repo/semantics/article Palavras-chave: Simvastatin/determination; Liquid chromatography/quantitative analysis; Tandem mass spectrometry/quantitative analysis; Human plasma/determination of simvastatin; Simvastatin/bioequivalence; Simvastatin/pharmacokinetics. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300543 Method development and validation for naratriptan determination in human plasma by HPLC with tandem mass spectrometry detection, and its application to bioequivalence study BJPS Challa,Balasekhara Reddy; Awen,Bahlul Zayed Shtaiwy; Chandu,Babu Rao; Shaik,Rihana Parveen. The authors developed a simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of naratriptan (NP) in human plasma using naratriptan-d3 (NPD3) as an internal standard (IS). Chromatographic separation was performed on a Zorbax SB-C18, 75 x 4.6 mm, 3.5 µm column with an isocratic mobile phase composed of 0.1% formic acid : acetonitrile (50:50 v/v), at a flow-rate of 0.6 mL/min. NP and NPD3 were detected with proton adducts at m/z 336.5→98.0 and 339.4→101.0 in selected reaction monitoring (SRM) positive mode, respectively. The liquid-liquid extraction method was used to extract the NP and NPD3. This method was validated over a linear concentration range of 0.1-25.0 ng/mL with a correlation... Tipo: Info:eu-repo/semantics/article Palavras-chave: Liquid chromatography/quantitative analysis; Mass spectrometry/quantitative analysis; Naratriptan/determination; Naratriptan/human plasma. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100003 Registros recuperados: 2 Primeira ... 1 ... Última

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