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Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost ArchiMer
Salin, Karine; Villasevil, Eugenia M.; Anderson, Graeme J.; Auer, Sonya K.; Selman, Colin; Hartley, Richard C.; Mullen, William; Chinopoulos, Christos; Metcalfe, Neil B..
Many animals experience periods of food shortage in their natural environment. It has been hypothesised that the metabolic responses of animals to naturally‐occurring periods of food deprivation may have long‐term negative impacts on their subsequent life‐history. In particular, reductions in energy requirements in response to fasting may help preserve limited resources but potentially come at a cost of increased oxidative stress. However, little is known about this trade‐off since studies of energy metabolism are generally conducted separately from those of oxidative stress. Using a novel approach that combines measurements of mitochondrial function with in vivo levels of hydrogen peroxide (H2O2) in brown trout (Salmo trutta), we show here that fasting...
Tipo: Text Palavras-chave: High-resolution respirometry; In vivo; Liver atrophy; MitoB probe; Mitochondrial respiratory state.
Ano: 2018 URL: https://archimer.ifremer.fr/doc/00449/56022/57540.pdf
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Chronic liver disease in cattle associated with ingestion of Brachiaria spp. Ciência Rural
Faccin,Tatiane Cargnin; Kommers,Glaucia Denise; Galiza,Glauco José Nogueira de; Pupin,Rayane Chitolina; Madureira,Renata Cunha; Lemos,Ricardo Antônio Amaral de.
ABSTRACT: One hundred and ninety livers condemned due to chronic disease (fibrosis) were evaluated in a bovine slaughterhouse over 12 months. Hepatic lymph nodes were also examined while still attached to livers. The major macroscopic lesion observed in the livers was moderate to severe atrophy of the left lobe associated with compensatory hypertrophy of the right lobe. Histologically, the main changes corresponded to sites of macroscopic lesions, and fibrosis was observed in all livers, along with bile duct hyperplasia and neovascularization. Masson's trichrome stain highlighted the fibrous connective tissue. Most of the livers analyzed had macrophages with foamy cytoplasm and a peripheral nucleus that infiltrated fibrotic areas. Immunohistochemistry...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Slaughtered bovines; Fibrosis; Liver atrophy; Foamy macrophages.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001102036
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