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| Cal,L.; Borteiro,C.; Benech,A.; Rodas,E.; Abreu,M.N.; Cruz,J. C.; González Montaña,J. R.. |
| The histological changes of the liver in ewes with pregnancy toxemia were characterized. Ten ewes were fed on grass ad libitum, and another ten were starved from day 130 of pregnancy for up to four days. Liver puncture biopsies were performed at days 70, 100, 130, and 140 of pregnancy, and at day 45 in postpartum. Seric hydroxybutyrate (HB), non-esterified fatty acids (NEFA), aspartate aminotransferase, and alkaline phosphatase were dosed. Histological preparations revealed similar incidence and intensity of mild liver steatosis in both groups at day 130. Starved ewes become toxemic (as indicated by HB), and at day 140 exhibited more severe injury in a higher proportion (9/9 vs. 4/10; P<0.01). Almost all of them (7/9) had large amounts of small lipid... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ewe; Liver biopsy; Microvesicular steatosis; Pregnancy toxemia. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352009000200004 |
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| Mendes,L.C.; Ferreira,P.A.; Miotto,N.; Zanaga,L.; Gonçales,E.; Lazarini,M.S.; Gonçales Júnior,F.L.; Stucchi,R.S.B.; Vigani,A.G.. |
| Although long regarded as the gold standard for liver fibrosis staging in chronic hepatitis C (CHC), liver biopsy (LB) implies both the risk of an invasive procedure and significant variability. The aim of this study was to evaluate the diagnostic performance for transient elastography (TE) and aspartate aminotransferase to platelet index (APRI) used alone and in combination compared to liver biopsy and to analyze false positive/negative results. Patients with CHC, and no previous clinical diagnosis of cirrhosis were enrolled to undergo liver biopsy, TE and APRI. A total of 182 adult patients with a median age of 55 years and median body mass index of 26.71 kg/m2 were analyzed. On LB, 56% of patients had significant levels of fibrosis (METAVIR F≥2) and 28%... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Liver biopsy; Noninvasive tests; APRI; Transient elastography; Accuracy; False results. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000900702 |
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| Oliveira Jr.,E.B.; Ferraz,M.L.G.; Perez,R.M.; Silva,A.E.B.; Lanzoni,V.P.; Granato,C.F.. |
| The objectives of the present study were to assess the in vitro-induced anti-hepatitis C virus (HCV) antibody production (IVIAP) in relation to the clinical, biochemical, virologic and histologic variables of patients with HCV infection. The study included 57 patients (60% males) with HCV infection (anti-HCV and HCV-RNA positive). Alanine aminotransferase (ALT) was elevated in 89% of the patients. Mean viral load was 542,241 copies/ml and histology of the liver showed chronic hepatitis in 27/52 (52%) and cirrhosis in 11/52 (21%) patients. IVIAP levels were determined by immunoenzymatic assay at median absorbance of 0.781 at 450 nm. IVIAP was negative in 14% of the patients. When groups with IVIAP levels above and below the median were compared, high IVIAP... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C; In vitro-induced antibody production; IVIAP; Hepatitis C virus-RNA; Liver biopsy; Anti-HCV antibodies. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000300011 |
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