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	Provedor de dados OAK (1) Autor Ishii, Toshiaki (1) Nishimura, Masakazu (1) Satoh, Eiki (1) 佐藤, 栄輝 (1) 石井, 利明 (1) Palavra-chave ACTIVATED PROTEIN-KINASE (1) ADAPTER PROTEIN (1) DEPENDENT GROWTH (1) EXTRACELLULAR-MATRIX (1) FACTOR RECEPTOR (1) MAP KINASE (1) NERVE GROWTH-FACTOR (1) PC12 CELLS (1) RHO-FAMILY GTPASES (1) SIGNAL-TRANSDUCTION (1) Mais... Ano 2001 (1) País Japan (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Integrin-linked kinase controls neurite outgrowth in N1E-115 neuroblastoma cells OAK Ishii, Toshiaki; Satoh, Eiki; Nishimura, Masakazu; 石井, 利明; 佐藤, 栄輝. Mouse N1E-115 cells grown on a laminin matrix exhibit neurite outgrowth in response to serum deprivation. Treatment of cells with an antibody against beta (1) integrin inhibits neurite outgrowth. Thus, beta (1) integrin is involved in the neuritogenesis of N1E-115 cells on a laminin matrix. Integrin-linked kinase (ILK), a recently identified cytoplasmic serine/threonine protein kinase that binds to the cytoplasmic domain of beta (1) integrin, has an important role in transmembrane signal transduction via integrins. We report that ILK is expressed in N1E-115 cells, the expression levels of which are constant under both normal and differentiating conditions. A stable transfection of a kinase-deficient mutant of ILK (DN-ILK) results in inhibition of neurite... Palavras-chave: NERVE GROWTH-FACTOR; ACTIVATED PROTEIN-KINASE; RHO-FAMILY GTPASES; MAP KINASE; PC12 CELLS; FACTOR RECEPTOR; EXTRACELLULAR-MATRIX; SIGNAL-TRANSDUCTION; DEPENDENT GROWTH; ADAPTER PROTEIN. Ano: 2001 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/746 Registros recuperados: 1 Primeira ... 1 ... Última

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