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	Provedor de dados 56 (2) 52 (1) 55 (1) Autor Alencar,B.C.G. de (1) Alves,Crésio (1) Brites,Carlos (1) Castelli,E.C. (1) Claser,C. (1) Gil,D.S. (1) Hu1,Wanyu (1) Huang,Qinghua (1) Li,Qing (1) Li,Xiaofan (1) Meyer,Isadora (1) Rodrigues,M.M. (1) Song,Qingxiao (1) Souza,Thaisa (1) Toralles,Maria Betânia P. (1) Tzelepis,F. (1) Veiga,L.C.S. (1) Wan,Bo (1) de Camargo,J.L.V. (1) Mais... Palavra-chave Major histocompatibility complex (4) Animal model (1) Busulfan (1) Chagas' disease (1) Fludarabine (1) HLA (1) HLA-A (1) Human leukocyte antigen-A (1) Immunodominance (1) Infectious diseases (1) Polymorphism (1) RFLP (1) Transfusion-associated graft-versus-host disease (1) Trypanosoma cruzi (1) Typing (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Info:eu-repo/semantics/other (2) Ano 2017 (1) 2009 (1) 2006 (1) 2005 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última Anti-CD3 Antibody Ameliorates Transfusion-Associated Graft-Versus-Host Disease in a Chemotherapy-Based Mouse Model With Busulfan and Fludarabine 52 Li,Xiaofan; Song,Qingxiao; Hu1,Wanyu; Wan,Bo; Huang,Qinghua; Li,Qing. ABSTRACT To establish a transfusion-associated graft-versus-host disease (TA-GVHD) mouse model with busulfan and fludarabine for effective treatment evaluation. BALB/c (H-2d) mice were injected with busulfan (15 mg/kg) and fludarabine (30 mg/kg) twice a day for 4 days. The mice were transfused with 106 T cell-depleted bone marrow (TCD-BM )and cells in different groups 3 days after chemotherapy: syngeneic BALB/c, MHC minor mismatch DBA/2 (H-2d), or MHC major mismatch C57BL/6(H2-b). Recipient BALB/c mice were injected with either blood only or blood+splenocyte. TA-GVHD was monitored in terms of body weight loss, clinical scores, and survival. Dexamethasone (50 mg/kg), cyclophosphamide (50 mg/kg), cyclosporine A (30 mg/kg), and anti-CD3 (1 mg/kg) were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Transfusion-associated graft-versus-host disease; Fludarabine; Busulfan; Animal model; Major histocompatibility complex. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100305 Immunogenetics and infectious diseases: special reference to the mayor histocompatibility complex 55 Alves,Crésio; Souza,Thaisa; Meyer,Isadora; Toralles,Maria Betânia P.; Brites,Carlos. Many studies have tried to identify genetic markers for infectious diseases, some of them have focused on human leukocyte antigens (HLA). The products of HLA genes interact with surface-specific receptors of T lymphocytes, resulting in activation of the host's immune response. Association of bacterial, viral, parasitic and fungal infections with the host's HLA has been widely investigated. The type and strength of this association differs among distinct populations, as well as among racial and/or ethnic groups. The new molecular methods for the identification of the HLA alleles, and the resulting new nomenclature, have contributed to a better understanding of this system. Unfortunately, this information has not been adequately transmitted to clinicians,... Tipo: Info:eu-repo/semantics/article Palavras-chave: HLA; Infectious diseases; Major histocompatibility complex. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200010 Typing class I HLA-A gene using a nested PCR-RFLP procedure 56 Castelli,E.C.; Gil,D.S.; Veiga,L.C.S.; de Camargo,J.L.V.. In order to detect several new HLA-A class I alleles that have been described since 1998, the original PCR-RFLP method developed to identify the 78 alleles recognized at that time at high resolution level was adapted by us for low and medium resolution levels using a nested PCR-RFLP approach. The results obtained from blood samples of 23 subjects using both the PCR-RFLP method and a commercial kit (MicroSSP1A®, One Lambda Inc.) showed an agreement higher than 95%. The PCR-RFLP adapted method was effective in low and medium resolution histocompatibility evaluations. Tipo: Info:eu-repo/semantics/other Palavras-chave: Human leukocyte antigen-A; HLA-A; Typing; RFLP; Polymorphism; Major histocompatibility complex. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000600004 Immunodominance: a new hypothesis to explain parasite escape and host/parasite equilibrium leading to the chronic phase of Chagas' disease? 56 Rodrigues,M.M.; Alencar,B.C.G. de; Claser,C.; Tzelepis,F.. Intense immune responses are observed during human or experimental infection with the digenetic protozoan parasite Trypanosoma cruzi. The reasons why such immune responses are unable to completely eliminate the parasites are unknown. The survival of the parasite leads to a parasite-host equilibrium found during the chronic phase of chagasic infection in most individuals. Parasite persistence is recognized as the most likely cause of the chagasic chronic pathologies. Therefore, a key question in Chagas' disease is to understand how this equilibrium is established and maintained for a long period. Understanding the basis for this equilibrium may lead to new approaches to interventions that could help millions of individuals at risk for infection or who are... Tipo: Info:eu-repo/semantics/other Palavras-chave: Chagas' disease; Trypanosoma cruzi; Immunodominance; Major histocompatibility complex. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000300001 Registros recuperados: 4 Primeira ... 1 ... Última

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