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| Wang,Z.H.; Zhu,W.; Tao,J.P.; Zhang,Q.Y.; Wei,M.. |
| Angiopoietin (Ang)-1 and Ang-2 interact in angiogenesis to activate the Tie-2 receptor, which may be involved in new vessel maturation and regression. Mast cells (MCs) are also involved in formation of new blood vessels and angiogenesis. The present study was designed to test whether MCs can mediate angiogenesis in myocardial microvascular endothelial cells (MMVECs). Using a rat MMVEC and MC co-culture system, we observed that Ang-1 protein levels were very low even though its mRNA levels were increased by MCs. Interestingly, MCs were able to enhance migration, proliferation, and capillary-like tube formation, which were associated with suppressed Ang-2 protein expression, but not Tie-2 expression levels. These MCs induced effects that could be reversed by... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Myocardial microvascular endothelial cells; Mast cell; Angiogenesis; Angiopoietin; Tie-2. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001100920 |
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| We have previously discovered a long-lasting enhancement of synaptic transmission in mammal autonomic ganglia caused by immunological activation of ganglionic mast cells. Subsequent to mast cell activation, lipid and peptide mediators are released which may modulate synaptic function. In this study we determined whether some mast cell-derived mediators, prostaglandin D2 (PGD2; 1.0 µM), platelet aggregating factor (PAF; 0.3 µM) and U44619 (a thromboxane analogue; 1.0 µM), and also endothelin-1 (ET-1; 0.5 µM) induce synaptic potentiation in the guinea pig superior cervical ganglion (SCG), and compared their effects on synaptic transmission with those induced by a sensitizing antigen, ovalbumin (OVA; 10 µg/ml). The experiments were carried out on SCGs... |
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Palavras-chave: Prostaglandin D; Platelet aggregating factor; Endothelin-1; Thromboxane; Mast cell; Synaptic plasticity. |
| Ano: 1997 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000700014 |
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| Vadstein, Olav; Bergh, Oivind; Gatesoupe, Joel; Galindo-villegas, Jorge; Mulero, Victoriano; Picchietti, Simona; Scapigliati, Giuseppe; Makridis, Pavlos; Olsen, Yngvar; Dierckens, Kristof; Defoirdt, Tom; Boon, Nico; De Schryver, Peter; Bossier, Peter. |
| For most marine aquaculture species, one of the main bottlenecks is the stable production of high quality juveniles. The high and unpredictable mortality in the first weeks after hatching of marine fish larvae remains a challenging problem that needs to be solved. The severity of the problem differs between species, but cannot be considered adequately solved for any species. Both scientific evidence and experience in hatcheries for a variety of fish, shrimp and shellfish species are accumulating as support for the hypothesis that detrimental fish-microbe interactions are the cause of these problems. Host-microbe interactions in reared fish are still poorly understood, except for a few pathogens, and empirical data of the quality required to test this... |
| Tipo: Text |
Palavras-chave: Host-microbe interaction; Mast cell; Microbial ecology; Piscidin; Quorum sensing. |
| Ano: 2013 |
URL: http://archimer.ifremer.fr/doc/00144/25510/23654.pdf |
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