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Effects of Chronic Administration of Efavirenz on the Chromatophilic Substance of the Intracranial Auditory Relay Centres of Adult Wistar Rats International Journal of Morphology
Adjene,J. O; Igbigbi,P. S.
The effects of chronic administration of efavirenz commonly used as part of highly active antiretroviral therapy (HAART) for the treatment of Human Immunodeficiency Virus (HIV) type-1 therapy on the chromatophilic substance of the intracranial auditory relay centre namely the inferior colliculus and medial geniculate body of adult wistar rats were carefully studied. The rats of both sexes (n=20), with an average weight of 200g were randomly assigned into treatment (n=10) and control (n=10) groups. The rats in the treatment group received 600 mg/70kg body weight of efavirenz dissolved in distilled water daily for 30 days through the orogastric tube. The control group received equal volume of distilled water daily for 30 days through the same route. The rats...
Tipo: Journal article Palavras-chave: Efavirenz; Chromatophilic substance; Inferior colliculus; Medial Geniculate body; Wistar rats.
Ano: 2012 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000300037
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