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Membrane adsorber for endotoxin removal BJPS
Almeida,Karina Moita de; Almeida,Maiara Maciel; Fingola,Fernando Faria; Ferraz,Helen Conceição.
ABSTRACT The surface of flat-sheet nylon membranes was modified using bisoxirane as the spacer and polyvinyl alcohol as the coating polymer. The amino acid histidine was explored as a ligand for endotoxins, aiming at its application for endotoxin removal from aqueous solutions. Characterization of the membrane adsorber, analysis of the depyrogenation procedures and the evaluation of endotoxin removal efficiency in static mode are discussed. Ligand density of the membranes was around 7 mg/g dry membrane, allowing removal of up to 65% of the endotoxins. The performance of the membrane adsorber prepared using nylon coated with polyvinyl alcohol and containing histidine as the ligand proved superior to other membrane adsorbers reported in the literature. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Endotoxins/removal; Membrane adsorber/performance; Histidine; Poly(vinyl alcohol)..
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000100019
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