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| Venson,Rafael; Wiens,Astrid; Correr,Cassyano Januário; Pontarolo,Roberto. |
| The objective is to provide an update on the clinical efficacy, safety and tolerability of the use of abatacept for treating rheumatoid arthritis. A systematic review (up to June 2011) followed by meta-analyses was performed. Randomized controlled clinical trials comparing abatacept at a dose of 10 mg/kg with a placebo, both with concomitant methotrexate, were used. Only high- or moderate-quality studies were included. The efficacy was evaluated based on changes in the ACR, DAS and HAQ; safety was assessed based on serious adverse events, serious infections, malignancies and deaths; tolerability was evaluated based on the withdrawals due to adverse events, serious adverse events and lack of efficacy. All these parameters were evaluated within one year of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Abatacept/efficacy; Rheumatoid arthritis/treatment; Meta-analyses. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400022 |
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| Sheehan, Emma V.; Vaz, Sandrine; Pettifer, Erin; Foster, Nicola L.; Nancollas, Sarah J.; Cousens, Sophie; Holmes, Luke; Facq, Jean-valery; Germain, Gregory; Attrill, Martin J.. |
| Managing ecological systems, which operate over large spatial scales, is inherently difficult and often requires sourcing data from different countries and organizations. The assumption might be made that data collected using similar methodologies are comparable, but this is rarely tested. Here, benthic video data recorded using different towed underwater video systems (TUVSs) were experimentally compared. Three technically different TUVSs were compared on different seabed types (rocky, mixed ground and sandy) in Kingmere Marine Conservation Zone, off the south coast of England. For each TUVS, species metrics (forward facing camera), seabed impact (backward facing camera) and operational performance (strengths and limitations of equipment and video... |
| Tipo: Text |
Palavras-chave: Environmental management; Marine protected area; Meta-analyses; Sampling impact; Towed video; Underwater imagery. |
| Ano: 2016 |
URL: https://archimer.ifremer.fr/doc/00319/42984/42659.pdf |
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