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	Provedor de dados 60 (1) Autor Bazzo,Giovana Carolina (1) Crenca,Janine Paula (1) Macedo,Aline Teixeira de (1) Pereira,Eduardo Manoel (1) Pezzini,Bianca Ramos (1) Silva,Virgínia Emiliana (1) Zétola,Melissa (1) Mais... Palavra-chave Drugs/controlled release (1) Drugs/in vitro study (1) Drugs/in vivo evaluation (1) Ibuprofen/release (1) Microspheres/preparation (1) Poly(hydroxybutyrate-co-hydroxyvalerate) (1) Poly(l-lactide) (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2012 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Microspheres prepared with biodegradable PHBV and PLA polymers as prolonged-release system for ibuprofen: in vitro drug release and in vivo evaluation 60 Bazzo,Giovana Carolina; Macedo,Aline Teixeira de; Crenca,Janine Paula; Silva,Virgínia Emiliana; Pereira,Eduardo Manoel; Zétola,Melissa; Pezzini,Bianca Ramos. In this study, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) and poly(l-lactide) (PLA) microspheres containing ibuprofen were prepared with the aim of prolonging the drug release. The oil-in-water (O/W) emulsion solvent evaporation technique was used, varying the polymer ratio. All formulations provided spherical particles with drug crystals on the surface and a porous and rough polymeric matrix when PHBV was used and smooth external surface when prepared with PLA. The in vitro dissolution profiles show that the formulation containing PHBV/PLA at the proportion of 30/70 presented the best results in terms of prolonging the ibuprofen release. The analysis of the concentration of ibuprofen in the blood of rats showed that maximum levels were achieved at... Tipo: Info:eu-repo/semantics/article Palavras-chave: Microspheres/preparation; Poly(hydroxybutyrate-co-hydroxyvalerate); Poly(l-lactide); Ibuprofen/release; Drugs/controlled release; Drugs/in vitro study; Drugs/controlled release; Drugs/in vivo evaluation. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400021 Registros recuperados: 1 Primeira ... 1 ... Última

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