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| Lee,K. H.; Hur,S. J.; Kim,S. N.; Yoo,S. H.; Shin,I. S.; Won,H. J.; Shin,K. H.; Hong,S. H.; Lee,S. H.; Min,H. K.; Park,S. N.. |
| To establish Korea National Standards for venoms and antivenoms, it is necessary to have standardized assay methods. In this study, we standardized a method to evaluate the antihemorrhagic potency of two horse-derived antivenoms using rabbit intracutaneous injection. We expressed the capability of these antivenoms to neutralize the hemorrhagic activities triggered by the venoms of Agkistrodon halys from Japan and Jiangzhe Agkistrodon halys from China as Minimum Hemorrhagic Dose (MHD). We also performed cross-neutralization tests employing the parallel line assay on different pairings of venoms and antivenoms to check the possibility of using Jiangzhe Agkistrodon halys venom as a substitute for the standard Agkistrodon halys venom in measurements of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antihemorrhagic potency; Minimum hemorrhagic dose; Jiangzhe Agkistrodon halys; Parallel line assay. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000300009 |
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