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	Provedor de dados BJMBR (2) Autor Balbi,A.P.C. (1) Coimbra,T.M. (1) Costa,R.S. (1) Francescato,H.D.C. (1) Horst,A. (1) Kolberg,C. (1) Marin,E.C.S. (1) Partata,W.A. (1) Ribeiro,M.F.M. (1) Riffel,A.P.K. (1) Santos,M.C.Q. (1) de Fraga,L.S. (1) de Souza,J.A. (1) Mais... Palavra-chave Mitogen-activated protein kinase (2) Angiotensin II (1) Angiotensin II antagonists (1) Antinociception (1) Chronic constriction (1) Mechanical threshold (1) Renal development (1) Sciatic functional index (1) Sciatic nerve (1) Sodium intake (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2017 (1) 2009 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última N-acetylcysteine downregulates phosphorylated p-38 expression but does not reverse the increased superoxide anion levels in the spinal cord of rats with neuropathic pain BJMBR Horst,A.; de Souza,J.A.; Santos,M.C.Q.; Riffel,A.P.K.; Kolberg,C.; Ribeiro,M.F.M.; de Fraga,L.S.; Partata,W.A.. We determined the effect of N-acetylcysteine (NAC) on the expression of the phosphorylated p38 (p-p38) protein and superoxide anion generation (SAG), two important players in the processing of neuropathic pain, in the lumbosacral spinal cord of rats with chronic constriction injury (CCI)-induced neuropathic pain. The sciatic functional index (SFI) was also measured to assess the functional recovery post-nerve lesion. Thirty-six male Wistar rats were divided equally into the following groups: Naive (rats did not undergo surgical manipulation); Sham (rats in which all surgical procedures involved in CCI were used except the ligature), and CCI (rats in which four ligatures were tied loosely around the right common sciatic nerve), which received 2, 4, or 8... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sciatic functional index; Chronic constriction; Sciatic nerve; Mitogen-activated protein kinase; Antinociception; Mechanical threshold. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000200605 Roles of mitogen-activated protein kinases and angiotensin II in renal development BJMBR Balbi,A.P.C.; Francescato,H.D.C.; Marin,E.C.S.; Costa,R.S.; Coimbra,T.M.. Experimental and clinical evidence suggests that angiotensin II (AII) participates in renal development. Renal AII content is several-fold higher in newborn rats and mice than in adult animals. AII receptors are also expressed in higher amounts in the kidneys of newborn rats. The kidneys of fetuses whose mother received a type 1 AII receptor (AT1) antagonist during gestation present several morphological alterations. Mutations in genes that encode components of the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Morphological changes were detected in the kidneys of 3-week-old angiotensin-deficient mice. Mitogen-activated protein kinases (MAPKs) are important mediators that transduce extracellular stimuli to... Tipo: Info:eu-repo/semantics/article Palavras-chave: Renal development; Angiotensin II; Mitogen-activated protein kinase; Angiotensin II antagonists; Sodium intake. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100007 Registros recuperados: 2 Primeira ... 1 ... Última

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