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	Provedor de dados Anais da ABC (AABC) (1) Biol. Res. (1) Genet. Mol. Biol. (1) Autor ALEXANDRINO BECKER,TÂNIA CRISTINA (1) ALVES DE CASTRO-PRADO,MARIALBA A (1) Busso,Cleverson (1) Castro-Prado,Marialba A. A. (1) Castro-Prado,Marialba Avezum Alves de (1) Chiuchetta,Simone Jurema Ruggeri (1) Mais... Palavra-chave Mitotic recombination (3) Parasexual cycle (2) Antineoplasm agents (1) Aspergillus nidulans (1) Conidiation (1) Conidiation mutants (1) Cremophor EL (1) Haploid recombinants (1) Homozygotization Index (1) Homozygotization index (1) Nitric oxide (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Journal article (1) Ano 2006 (1) 2005 (1) 2004 (1) País Brazil (2) Chile (1) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans Anais da ABC (AABC) Busso,Cleverson; Castro-Prado,Marialba A. A.. Cremophor EL is a solubilizer and emulsifier agent used in the pharmaceutical and foodstuff industries. The solvent is the principal constituent of paclitaxel's clinical formulation vehicle. Since mitotic recombination plays a crucial role in multistep carcinogenesis, the study of the recombinagenic potential of chemical compounds is of the utmost importance. In our research genotoxicity of cremophor EL has been studied by using an uvsH//uvsH diploid strain of Aspergillus nidulans. Since it spends a great part of its cell cycle in the G2period, this fungus is a special screening system for the study of mitotic recombination induced by chemical substances. Homozygotization Indexes (HI) for paba and bi markers from heterozygous B211//A837 diploid strain were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aspergillus nidulans; Mitotic recombination; Cremophor EL; Homozygotization Index; Antineoplasm agents. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100005 Parasexuality in asexual development mutants of Aspergillus nidulans Biol. Res. ALEXANDRINO BECKER,TÂNIA CRISTINA; ALVES DE CASTRO-PRADO,MARIALBA A. The parasexual cycle with parameiosis has been characterized previously by the occurrence of genetic recombination and haploidization inside heterokaryotic hyphae prior to conidial formation. The aim of current research was to characterize, through genetic and cytological analyses, an asexual development mutant strain of A. nidulans and to use it to obtain parameiotic segregants. Analyses showed the medusa phenotype of the B84 strain, whose mutant allele was mapped in the chromosome I. The heterokaryons B84(med)//G422(med+) and B84(med)//G839(brl) were formed in liquid MM+2% CM and inoculated in the appropriate selective media. Two mitotic segregant groups were obtained: aneuploids and haploid stable recombinants. Mitotic segregants, wild-types, and... Tipo: Journal article Palavras-chave: Parasexual cycle; Conidiation mutants; Mitotic recombination; Haploid recombinants. Ano: 2006 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000200012 Genotoxic evaluation of sodium nitroprusside in Aspergillus nidulans Genet. Mol. Biol. Chiuchetta,Simone Jurema Ruggeri; Castro-Prado,Marialba Avezum Alves de. The exogenous nitric oxide donor, sodium nitroprusside, evaluated the recombinogenic potential of nitric oxide. Drug inhibited mycelial growth and conidiation in A757 Aspergillus nidulans master strain. Two heterozygous diploid strains, one wild (uvsH+//uvsH+) and the other defective to DNA repair (uvsH//uvsH) were used for recombinagenesis tests. Sodium nitroprusside recombinogenic effect was evaluated by the induction of homozygosis of recessive genes, originally present in heterozygous condition. Results show that sodium nitroprusside (40 muM, 80 muM and 160 muM) is effective in inducing mitotic crossing-over in diploid cells of A. nidulans. Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Parasexual cycle; Homozygotization index; Conidiation; Mitotic recombination. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000500023 Registros recuperados: 3 Primeira ... 1 ... Última

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