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Oxidative stress in sepsis. Possible production of free radicals through an erythrocyte-mediated positive feedback mechanism BJID
Oliveira,Yanaihara Pinchemel Amorim de; Pontes-de-Carvalho,Lain Carlos; Couto,Ricardo David; Noronha-Dutra,Alberto Augusto.
Abstract Background: Sepsis is an illness with a high morbidity for which no effective treatment exists. Its treatment has a high cost because it usually requires an intensive care unit and expensive antibiotics. The present study focus in the production of reactive oxygen species in the early stages of sepsis. This study aimed at investigating the production of reactive oxygen specie during the inflammatory response in patients with sepsis. Methods: Reactive oxygen specie production and insoluble myeloperoxidase obtained from fresh whole blood were measured by photon counting chemiluminescence in the blood of 18 septic patients and 12 healthy individuals. Modified red blood cells were evaluated by staining of blood smears. The production of reactive...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sepsis; Oxidative stress; Inflammation; Modified erythrocytes.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100019
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