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Development and characterization of pullulan-polymethacrylate free films as potential material for enteric drug release 60
Lima,Isabela Angeli de; Pomin,Suelen Plaza; Cavalcanti,Osvaldo Albuquerque.
ABSTRACT Free films of pullulan-polymethacrylate associations were produced by casting process to develop a novel target-specific material. For characterization, tests of water vapor permeability, swelling index, infrared absorption spectroscopy, thermogravimetric analysis, scanning electron microscopy and mechanical analysis were performed. The polysaccharide concentration directly influenced vapor permeability and swelling, increasing the values of the latter up to five times when added in a proportion of 20% (per weight). The individual properties of each polymer were maintained, and chemical interactions were not detected. The films were found to be thermally stable and they had unaltered mechanical properties with the addition of the polysaccharide....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Films; Polymeric material; Modified release/enteric release/oral delivery/controlled release; Glucans; Eudragit; Physicochemical characterization.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300601
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